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Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling

Journal of pharmaceutical sciences, 2022-01, Vol.111 (1), p.262-273

2022

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Pharmaceutics, 2024-01, Vol.16 (1), p.96

2024

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Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.305-315

2019

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Pharmaceutics, 2021-08, Vol.13 (9), p.1325

2021

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Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

The AAPS journal, 2008, Vol.10 (1), p.213-226

2008

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In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Molecular pharmaceutics, 2012-03, Vol.9 (3), p.492-504

2012

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The AAPS journal, 2009-06, Vol.11 (2), p.323-334

2009

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The AAPS journal, 2021-06, Vol.23 (4), p.89-89, Article 89

2021

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Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

Drug metabolism and disposition, 2019-08, Vol.47 (8), p.818-831

2019

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The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.268-278

2019

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In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100899, Article 100899

2024

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The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1808-1818

2016

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Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Journal of chemical education, 2020-08, Vol.97 (8), p.2212-2220

2020

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

The AAPS journal, 2019-07, Vol.21 (4), p.65, Article 65

2019

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.821-830

2018

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.831-839

2018

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Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

Bioorganic & medicinal chemistry, 2007-07, Vol.15 (14), p.4985-5002

2007

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Similar or Not? Comparison of Dissolution Profiles of Different Hydroxypropylmethyl Cellulose (HPMC) Capsules

Dissolution technologies, 2018-02, Vol.25 (1), p.6-11

2018

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Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine

Molecular pharmaceutics, 2012-04, Vol.9 (4), p.815-822

2012

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Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition

The AAPS journal, 2013-07, Vol.15 (3), p.787-796

2013

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Modeling of absorption

Methods in molecular biology (Clifton, N.J.), 2012, Vol.929, p.313

2012

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PQRI Workshop Report: Application of IVIVC in Formulation Development

Dissolution technologies, 2014-05, Vol.21 (2), p.51-58

Van Buskirk, Glenn A.

2014

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Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

Journal of pharmaceutical sciences, 1998-11, Vol.87 (11), p.1286-1291

1998

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Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

Similar or Not? Comparison of Dissolution Profiles of Different Hydroxypropylmethyl Cellulose (HPMC) Capsules

Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine

Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition

Modeling of absorption

PQRI Workshop Report: Application of IVIVC in Formulation Development

Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

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