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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

Volltextzugriff (PDF)

Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

European journal of drug metabolism and pharmacokinetics, 2000-01, Vol.25 (1), p.49-58

2000

Volltextzugriff (PDF)

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

International journal of clinical pharmacology and therapeutics, 1997-10, Vol.35 (10), p.469

1997

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Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

European journal of clinical pharmacology, 1996, Vol.49 (4), p.251-254

1996

Volltextzugriff (PDF)

Sparse sampling for assessment of drug exposure in toxicological studies

European journal of drug metabolism and pharmacokinetics, 1996-04, Vol.21 (2), p.105-111

1996

Volltextzugriff (PDF)

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

European journal of clinical pharmacology, 1994-06, Vol.46 (5), p.389-391

1994

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Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

Volltextzugriff (PDF)

Pharmacokinetic and pharmacodynamic data and models in clinical trials

European journal of drug metabolism and pharmacokinetics, 1993-01, Vol.18 (1), p.61-76

1993

Volltextzugriff (PDF)

New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

European journal of clinical pharmacology, 1993-09, Vol.45 (2), p.93-94

1993

Volltextzugriff (PDF)

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

Cancer chemotherapy and pharmacology, 1991-01, Vol.28 (2), p.123-129

1991

Volltextzugriff (PDF)

Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

Biometrics, 1988-09, Vol.44 (3), p.673-683

1988

Volltextzugriff (PDF)

Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney

The Journal of biological chemistry, 1981-01, Vol.256 (1), p.142-147

1981

Volltextzugriff (PDF)

La méthode de la clairance rénale pour l'individualisation des posologies du lithium en routine hospitalière

Encéphale, 1984, Vol.10 (5), p.223-230

1984

Volltextzugriff (PDF)

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

American Journal of Physiology: Cell Physiology, 1985-01, Vol.248 (1), p.C88-C101

1985

Volltextzugriff (PDF)

Alternative Approaches to Estimation of Population Pharmacokinetic Parameters: Comparison with the Nonlinear Mixed-Effect Model

Drug metabolism reviews, 1984, Vol.15 (1-2), p.265-292

1984

Volltextzugriff (PDF)

Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics

Therapeutic innovation & regulatory science, 1995, Vol.29 (3), p.997-1019

1995

Volltextzugriff (PDF)

Application of Sparse Sampling Approaches in Rodent Toxicokinetics: A Prospective View

Therapeutic innovation & regulatory science, 1994, Vol.28 (1), p.263-279

1994

Volltextzugriff (PDF)

Isoniazid plasma and lymph kinetics after intravenous injection in dogs

Arzneimittel-Forschung, 1984, Vol.34 (10), p.1283

1984

Volltextzugriff (PDF)

An application of population pharmacokinetics to the clinical use of cyclosporine in bone marrow transplant patients

Transplantation proceedings, 1988-04, Vol.20 (2 Suppl 2), p.466-470

1988

Volltextzugriff (PDF)

A Time-Lag Model for Pharmacokinetics of Drugs Subject to Enterohepatic Circulation

Journal of pharmaceutical sciences, 1982-03, Vol.71 (3), p.297-302

1982

Volltextzugriff (PDF)

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

American Journal of Physiology: Cell Physiology, 1985, Vol.17 (1), p.C88-C101

1985

Volltextzugriff (PDF)

Can compartment models account for nonmonotonicity in pharmacokinetics?

Mathematical biosciences, 1982, Vol.58 (1), p.19-25

1982

Volltextzugriff (PDF)

Bioequivalence of dosage forms. The confidence interval approach. Westlake's method (author's transl)

Therapie, 1980-11, Vol.35 (6), p.743

1980

Volltextzugriff (PDF)

Finite element simulation of gas transport in proximal respiratory airways: Comparison with experimental data

Computers and biomedical research, 1981-12, Vol.14 (6), p.493-505

1981

Volltextzugriff (PDF)

Mean residence time in the body. A new pharmacokinetic parameter?

Therapie, 1986-01, Vol.41 (1), p.1

1986

Volltextzugriff (PDF)

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Pharmacokinetic/pharmacodynamic modeling in drug development

Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

Sparse sampling for assessment of drug exposure in toxicological studies

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Pharmacokinetic and pharmacodynamic data and models in clinical trials

New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney

La méthode de la clairance rénale pour l'individualisation des posologies du lithium en routine hospitalière

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

Alternative Approaches to Estimation of Population Pharmacokinetic Parameters: Comparison with the Nonlinear Mixed-Effect Model

Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics

Application of Sparse Sampling Approaches in Rodent Toxicokinetics: A Prospective View

Isoniazid plasma and lymph kinetics after intravenous injection in dogs

An application of population pharmacokinetics to the clinical use of cyclosporine in bone marrow transplant patients

A Time-Lag Model for Pharmacokinetics of Drugs Subject to Enterohepatic Circulation

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

Can compartment models account for nonmonotonicity in pharmacokinetics?

Bioequivalence of dosage forms. The confidence interval approach. Westlake's method (author's transl)

Finite element simulation of gas transport in proximal respiratory airways: Comparison with experimental data

Mean residence time in the body. A new pharmacokinetic parameter?

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