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Molecular Structure and Function of the Glycine Receptor Chloride Channel

Physiological reviews, 2004-10, Vol.84 (4), p.1051-1095

Lynch, Joseph W

2004

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The impact of human hyperekplexia mutations on glycine receptor structure and function

Molecular brain, 2014-01, Vol.7 (1), p.2-2

2014

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Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Nature neuroscience, 2018-03, Vol.21 (3), p.384

2018

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Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Neurobiology of disease, 2020-07, Vol.140, p.104850-104850, Article 104850

2020

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An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

The Journal of biological chemistry, 2010-05, Vol.285 (20), p.14890-14897

2010

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Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

PLoS pathogens, 2017-10, Vol.13 (10), p.e1006663-e1006663

2017

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An outline of desensitization in pentameric ligand-gated ion channel receptors

Cellular and molecular life sciences : CMLS, 2013-04, Vol.70 (7), p.1241-1253

2013

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Correlating Structural and Energetic Changes in Glycine Receptor Activation

The Journal of biological chemistry, 2015-02, Vol.290 (9), p.5621-5634

2015

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Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

Neurobiology of disease, 2017-12, Vol.108, p.213-224

2017

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GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

PLoS pathogens, 2019-01, Vol.15 (1), p.e1007570-e1007570

2019

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Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15332-15341

2016

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Stoichiometry and Subunit Arrangement of α1β Glycine Receptors As Determined by Atomic Force Microscopy

Biochemistry (Easton), 2012-07, Vol.51 (26), p.5229-5231

2012

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Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

Frontiers in molecular neuroscience, 2015-09, Vol.8, p.55-55

2015

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A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Neurobiology of disease, 2015-04, Vol.76, p.87-97

2015

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The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Structure (London), 2014-10, Vol.22 (10), p.1399-1407

2014

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Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Cell & bioscience, 2022-04, Vol.12 (1), p.1-48, Article 48

2022

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Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP

ACS chemical biology, 2017-03, Vol.12 (3), p.805-813

2017

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Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

Frontiers in molecular neuroscience, 2012-01, Vol.5, p.60

2012

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Molecular pharmacology of the glycine receptor chloride channel

Current pharmaceutical design, 2007-08, Vol.13 (23), p.2350

2007

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Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4420-4425

2013

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Effects of GABAA Receptor α3 Subunit Epilepsy Mutations on Inhibitory Synaptic Signaling

Frontiers in molecular neuroscience, 2020-11, Vol.13, p.602559-602559

2020

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Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

Frontiers in molecular neuroscience, 2022-04, Vol.15, p.886729-886729

2022

Volltextzugriff (PDF)

Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells

PloS one, 2013-03, Vol.8 (3), p.e58479-e58479

2013

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Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

The Journal of neuroscience, 2017-08, Vol.37 (33), p.7948-7961

2017

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SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit

Frontiers in molecular neuroscience, 2018-03, Vol.11, p.89-89

2018

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Molecular Structure and Function of the Glycine Receptor Chloride Channel

The impact of human hyperekplexia mutations on glycine receptor structure and function

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

An outline of desensitization in pentameric ligand-gated ion channel receptors

Correlating Structural and Energetic Changes in Glycine Receptor Activation

Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

Stoichiometry and Subunit Arrangement of α1β Glycine Receptors As Determined by Atomic Force Microscopy

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

Molecular pharmacology of the glycine receptor chloride channel

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Effects of GABAA Receptor α3 Subunit Epilepsy Mutations on Inhibitory Synaptic Signaling

Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit

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