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The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10616

Lugnier, Claire

2022

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Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs

Current pharmaceutical design, 2010-03, Vol.16 (9), p.1114

2010

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Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7525-7545

2012

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The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure

Journal of clinical medicine, 2019-10, Vol.8 (10), p.1746

2019

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Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

PloS one, 2015-12, Vol.10 (12), p.e0145291-e0145291

2015

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Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families

Cellular signalling, 2017-11, Vol.39, p.55-65

2017

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NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Frontiers in pharmacology, 2020-08, Vol.11, p.1266-1266

2020

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Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues

Current pharmaceutical design, 2018-01, Vol.24 (46), p.5580

2018

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Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II

PloS one, 2010-12, Vol.5 (12), p.e14227-e14227

2010

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Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor

PloS one, 2012-01, Vol.7 (1), p.e28899-e28899

2012

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Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Antioxidants, 2019-04, Vol.8 (4), p.93

2019

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Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (±)-naringenin

Planta medica, 2005-02, Vol.71 (2), p.99-107

2005

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Cyclic nucleotide phosphodiesterase (PDE) implication in lupus erythematosus: Effect of a new PDE4 inhibitor

Immunome research, 2017-01, Vol.13 (S1), p.44

Lugnier, Claire

2017

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New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6567-6572

2011

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NCS 613, a PDE4 inhibitor, by increasing cAMP level suppresses systemic inflammation and immune complexes deposition in kidney of MRL/lpr lupus- prone mice

Biochimica et biophysica acta. Molecular basis of disease, 2021-03, Vol.1867 (3), p.166019-166019, Article 166019

2021

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Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin

Naunyn-Schmiedeberg's archives of pharmacology, 2004-12, Vol.370 (6), p.452-463

2004

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Molecular organization of bovine rod cGMP-phosphodiesterase 6

Journal of molecular biology, 2001-07, Vol.310 (4), p.781-791

2001

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Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions

Cellular and molecular life sciences : CMLS, 2017-05, Vol.74 (10), p.1883-1893

2017

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Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

Current drug discovery technologies, 2005-09, Vol.2 (3), p.161

2005

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Generation of PDE4 knockout mice by gene targeting

Methods in molecular biology (Clifton, N.J.), 2005, Vol.307, p.191

2005

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Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

European journal of medicinal chemistry, 2019-09, Vol.177, p.269-290

2019

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Purification of PDE6 isozymes from mammalian retina

Methods in molecular biology (Clifton, N.J.), 2005, Vol.307, p.125

2005

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Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases

Methods in molecular biology (Clifton, N.J.), 2005, Vol.307, p.225

2005

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Coupling of I1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline

Molecular pharmacology, 2000-06, Vol.57 (6), p.1142

2000

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Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei

Biochimica et biophysica acta, 1999-11, Vol.1472 (3), p.431-446

1999

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The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches

Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs

Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure

Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families

NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues

Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II

Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor

Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (±)-naringenin

Cyclic nucleotide phosphodiesterase (PDE) implication in lupus erythematosus: Effect of a new PDE4 inhibitor

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

NCS 613, a PDE4 inhibitor, by increasing cAMP level suppresses systemic inflammation and immune complexes deposition in kidney of MRL/lpr lupus- prone mice

Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin

Molecular organization of bovine rod cGMP-phosphodiesterase 6

Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions

Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

Generation of PDE4 knockout mice by gene targeting

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Purification of PDE6 isozymes from mammalian retina

Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases

Coupling of I1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline

Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei

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