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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

Cancer letters, 2015-04, Vol.359 (1), p.47-56

2015

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circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Molecular cancer, 2020-05, Vol.19 (1), p.82-82, Article 82

2020

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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Gastroenterology (New York, N.Y. 1943), 2015-12, Vol.149 (7), p.1884-1895.e4

2015

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Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

Cancer treatment reviews, 2014-08, Vol.40 (7), p.862-871

Ciruelos Gil, Eva Maria

2014

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Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Cancer treatment reviews, 2013-12, Vol.39 (8), p.935-946

2013

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The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

PLoS biology, 2019-10, Vol.17 (10), p.e3000509-e3000509

2019

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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Scientific reports, 2022-04, Vol.12 (1), p.5924-5924, Article 5924

2022

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Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

Frontiers in immunology, 2018-03, Vol.9, p.575-575

2018

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Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Brain research, 2013-02, Vol.1494, p.1-8

2013

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mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

Frontiers in immunology, 2022-02, Vol.12, p.774103-774103

2022

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The PI3K/Akt Pathway in Meta-Inflammation

International journal of molecular sciences, 2022-12, Vol.23 (23), p.15330

2022

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Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Gastroenterology (New York, N.Y. 1943), 2017-07, Vol.153 (1), p.277-291.e19

2017

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PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

Neoplasia (New York, N.Y.), 2024-05, Vol.51, p.100987-100987, Article 100987

2024

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Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells

PloS one, 2014-04, Vol.9 (4), p.e94496-e94496

2014

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MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

Cell death & disease, 2017-05, Vol.8 (5), p.e2796-e2796

2017

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Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects

International journal of molecular sciences, 2022-09, Vol.23 (17), p.10132

2022

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Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

Cancer letters, 2014-02, Vol.343 (2), p.179-189

2014

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PI3K and AKT: Unfaithful Partners in Cancer

International journal of molecular sciences, 2015-09, Vol.16 (9), p.21138-21152

2015

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Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

PloS one, 2014-04, Vol.9 (4), p.e95219-e95219

2014

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Sequential conversion of PtdIns3P to PtdIns(3,5)P 2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy

Autophagy, 2023-04, Vol.19 (4), p.1365-1367

2023

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Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

Gynecologic oncology, 2016-09, Vol.142 (3), p.548-556

2016

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C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits

Gastroenterology (New York, N.Y. 1943), 2016-05, Vol.150 (5), p.1183-1195.e16

2016

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Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression

PloS one, 2011-05, Vol.6 (5), p.e20164

2011

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Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells

PloS one, 2012-08, Vol.7 (8), p.e44107

2012

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Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

International journal of molecular sciences, 2015-09, Vol.16 (9), p.22976-22988

2015

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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

The PI3K/Akt Pathway in Meta-Inflammation

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures

Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells

MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

PI3K and AKT: Unfaithful Partners in Cancer

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

Sequential conversion of PtdIns3P to PtdIns(3,5)P 2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy

Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits

Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells

Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

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