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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

Cell death and differentiation, 2013-04, Vol.20 (4), p.558-566

2013

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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4507

2020

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Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Molecular cell, 2020-10, Vol.80 (1), p.164-174.e4

2020

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Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1353

2022

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Mechanisms of ATM Activation

Annual review of biochemistry, 2015-06, Vol.84 (1), p.711-738

Paull, Tanya T

2015

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MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Cell death & disease, 2021-07, Vol.12 (7), p.691-691, Article 691

2021

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The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

PLoS biology, 2019-10, Vol.17 (10), p.e3000509-e3000509

2019

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The PI3K/Akt Pathway in Meta-Inflammation

International journal of molecular sciences, 2022-12, Vol.23 (23), p.15330

2022

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Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Journal of molecular biology, 2021-04, Vol.433 (8), p.166838-166838, Article 166838

2021

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

Molecular cell, 2011-04, Vol.42 (1), p.84-95

2011

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Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

The Journal of biological chemistry, 2015-07, Vol.290 (28), p.17495-17504

2015

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

Cancer discovery, 2011-07, Vol.1 (2), p.170-185

2011

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Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Aging (Albany, NY.), 2020-04, Vol.12 (8), p.6852-6864

2020

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TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Science signaling, 2017-07, Vol.10 (486)

2017

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Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Journal of Virology, 2013-03, Vol.87 (5), p.2508-2517

2013

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Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Brain research, 2013-02, Vol.1494, p.1-8

2013

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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.12176-12181

2018

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Molecules in medicine mini-review: isoforms of PI3K in biology and disease

Journal of Molecular Medicine, 2016-01, Vol.94 (1), p.5-11

2016

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Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Journal of neuroinflammation, 2021-11, Vol.18 (1), p.276-276, Article 276

2021

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Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation

Reproductive toxicology (Elmsford, N.Y.), 2024-03, Vol.124, p.108545, Article 108545

2024

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Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

American journal of physiology. Heart and circulatory physiology, 2012-01, Vol.302 (1), p.H105-H114

2012

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A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

Nature cell biology, 2015-07, Vol.17 (7), p.930-942

2015

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mTOR Links Tumor Immunity and Bone Metabolism: What are the Clinical Implications?

International journal of molecular sciences, 2019-11, Vol.20 (23), p.5841

2019

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Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

PloS one, 2014-04, Vol.9 (4), p.e95219-e95219

2014

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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Mechanisms of ATM Activation

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

The PI3K/Akt Pathway in Meta-Inflammation

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation

Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

mTOR Links Tumor Immunity and Bone Metabolism: What are the Clinical Implications?

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

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