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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

Cell death and differentiation, 2013-04, Vol.20 (4), p.558-566

2013

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Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1353

2022

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The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

PLoS biology, 2019-10, Vol.17 (10), p.e3000509-e3000509

2019

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MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Cell death & disease, 2021-07, Vol.12 (7), p.691-691, Article 691

2021

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Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

Journal of cellular physiology, 2018-06, Vol.233 (6), p.4634-4642

2018

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Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Journal of molecular biology, 2021-04, Vol.433 (8), p.166838-166838, Article 166838

2021

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

Molecular cell, 2011-04, Vol.42 (1), p.84-95

2011

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The PI3K/Akt Pathway in Meta-Inflammation

International journal of molecular sciences, 2022-12, Vol.23 (23), p.15330

2022

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TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Science signaling, 2017-07, Vol.10 (486)

2017

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Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Aging (Albany, NY.), 2020-04, Vol.12 (8), p.6852-6864

2020

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Molecules in medicine mini-review: isoforms of PI3K in biology and disease

Journal of Molecular Medicine, 2016-01, Vol.94 (1), p.5-11

2016

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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.12176-12181

2018

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Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation

Reproductive toxicology (Elmsford, N.Y.), 2024-03, Vol.124, p.108545-108545, Article 108545

2024

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A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

Nature cell biology, 2015-07, Vol.17 (7), p.930

2015

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mTOR Links Tumor Immunity and Bone Metabolism: What are the Clinical Implications?

International journal of molecular sciences, 2019-11, Vol.20 (23), p.5841

2019

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The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance

Journal of ethnopharmacology, 2016-11, Vol.192, p.382-389

2016

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Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

Current biology, 2011-02, Vol.21 (3), p.173-183

2011

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Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

eLife, 2021-07, Vol.10

2021

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Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer

Genome research, 2012-11, Vol.22 (11), p.2120

2012

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Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

Journal of virology, 2015-11, Vol.89 (22), p.11420-11437

2015

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SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

Nature cell biology, 2017-05, Vol.19 (5), p.504

2017

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TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

Cancer letters, 2013-05, Vol.332 (1), p.63-73

2013

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Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3‑Kinase/Akt Phosphorylation

Journal of medicinal chemistry, 2022-05, Vol.65 (10), p.7399-7413

2022

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CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT

European journal of cancer (1990), 2021-03, Vol.145, p.92-108

2021

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Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo

Journal of ethnopharmacology, 2024-03, Vol.322, p.117592-117592, Article 117592

2024

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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

The PI3K/Akt Pathway in Meta-Inflammation

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

mTOR Links Tumor Immunity and Bone Metabolism: What are the Clinical Implications?

The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance

Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3‑Kinase/Akt Phosphorylation

CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT

Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo

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