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Desensitization of G protein-coupled receptors and neuronal functions

Annual review of neuroscience, 2004-01, Vol.27 (1), p.107-144

2004

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Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity

Molecular and Cellular Biology, 2000-11, Vol.20 (22), p.8352-8363

2000

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Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

The Journal of biological chemistry, 1994-01, Vol.269 (2), p.1125-1130

1994

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Structure and mechanism of the G protein-coupled receptor kinases

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.23735-23738

1993

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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

The Journal of biological chemistry, 1999-05, Vol.274 (20), p.13978-13984

1999

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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

The Journal of biological chemistry, 1994-03, Vol.269 (9), p.6832-6841

1994

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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase

The Journal of biological chemistry, 1993-04, Vol.268 (11), p.8256-8260

1993

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Turning off the signal: desensitization of β‐adrenergic receptor function

The FASEB journal, 1990-08, Vol.4 (11), p.2881-2889

1990

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Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Circulation research, 2002-10, Vol.91 (8), p.672-680

2002

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G PROTEIN-COUPLED RECEPTOR KINASES

Annual review of biochemistry, 1998-01, Vol.67 (1), p.653-692

1998

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Oncogene, 2001-03, Vol.20 (13), p.1532-1539

2001

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Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C

Molecular pharmacology, 1995-08, Vol.48 (2), p.173-177

1995

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Constitutively active mutants of the alpha 2-adrenergic receptor

The Journal of biological chemistry, 1993-08, Vol.268 (22), p.16483-16487

1993

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β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9429-9436

2002

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Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Annual review of pharmacology and toxicology, 2012-01, Vol.52 (1), p.179-197

2012

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In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Circulation (New York, N.Y.), 1999-08, Vol.100 (6), p.648-653

1999

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Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems

The Journal of biological chemistry, 1992-04, Vol.267 (12), p.8558-8564

1992

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The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

The Journal of biological chemistry, 1993-05, Vol.268 (13), p.9161-9164

1993

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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

The Journal of biological chemistry, 2000-03, Vol.275 (13), p.9572-9580

2000

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Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35403-35411

2003

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β-Adrenergic receptors: biochemical mechanisms of physiological regulation

Physiological reviews, 1984-04, Vol.64 (2), p.661-743

1984

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Molecular mechanisms of receptor desensitization using the β -adrenergic receptor-coupled adenylate cyclase system as a model

Nature (London), 1985-09, Vol.317 (6033), p.124-129

1985

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Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype

The Journal of biological chemistry, 1990-05, Vol.265 (14), p.8183-8189

1990

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Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

Nature (London), 1987-05, Vol.327 (6117), p.67-70

1987

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Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance

The Journal of biological chemistry, 2004-01, Vol.279 (3), p.1810-1818

2004

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Desensitization of G protein-coupled receptors and neuronal functions

Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

Structure and mechanism of the G protein-coupled receptor kinases

Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase

Turning off the signal: desensitization of β‐adrenergic receptor function

Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

G PROTEIN-COUPLED RECEPTOR KINASES

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C

Constitutively active mutants of the alpha 2-adrenergic receptor

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways

β-Adrenergic receptors: biochemical mechanisms of physiological regulation

Molecular mechanisms of receptor desensitization using the β -adrenergic receptor-coupled adenylate cyclase system as a model

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance

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