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Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

The Journal of biological chemistry, 1989-07, Vol.264 (21), p.12657-12665

1989

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The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

The Journal of biological chemistry, 1993-05, Vol.268 (13), p.9161-9164

1993

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Mitogenic signaling via G protein-coupled receptors

Endocrine reviews, 1996-12, Vol.17 (6), p.698-714

1996

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Model Systems for the Study of Seven-Transmembrane-Segment Receptors

Annual review of biochemistry, 1991, Vol.60 (1), p.653-688

1991

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Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function

Gene therapy, 1999-07, Vol.6 (7), p.1298-1304

1999

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Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein

The Journal of biological chemistry, 1985-06, Vol.260 (11), p.7094-7101

1985

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2001: An AAP (Association of American Physicians) odyssey

The Journal of clinical investigation, 2001-10, Vol.108 (7), p.s9-s13

Lefkowitz, R J

2001

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J018 The deubiquitinases USP33 and USP20 collaboratively regulate beta2 adrenergic receptor recycling and resensitization

Archives of cardiovascular diseases, 2009, Vol.102, p.S108-S109

2009

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Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

Nature (London), 1997-11, Vol.390 (6655), p.88-91

1997

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β2-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids

The Journal of biological chemistry, 1988, Vol.263 (19), p.9067-9070

1988

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Site-directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor: localization of regions involved in G protein-receptor coupling

The Journal of biological chemistry, 1988, Vol.263 (31), p.15985-15992

1988

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Protein kinases that phosphorylate activated G protein‐coupled receptors

The FASEB journal, 1995-02, Vol.9 (2), p.175-182

1995

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G Proteins in Medicine

The New England journal of medicine, 1995-01, Vol.332 (3), p.186-187

Lefkowitz, Robert J

1995

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Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding

The Journal of clinical investigation, 1976-01, Vol.57 (1), p.149-155

1976

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A mutation-induced activated state of the β2-adrenergic receptor : extending the ternary complex model

The Journal of biological chemistry, 1993-03, Vol.268 (7), p.4625-4636

1993

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Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor: phosphorylation of the receptor and regulation of its mRNA level

The Journal of biological chemistry, 1989, Vol.264 (28), p.16786-16792

1989

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The subunit story thickens

Nature (London), 1992-07, Vol.358 (6385), p.372-372

Lefkowitz, R. J

1992

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Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment

The Journal of biological chemistry, 1985-04, Vol.260 (8), p.4561-4564

1985

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Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes

Molecular pharmacology, 1982-01, Vol.21 (1), p.5-16

1982

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Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

Nature (London), 1995-08, Vol.376 (6543), p.781-784

1995

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Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization

The Journal of biological chemistry, 1984-04, Vol.259 (7), p.4389-4395

1984

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Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation (∗)

The Journal of biological chemistry, 1995-07, Vol.270 (29), p.17148-17153

1995

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Binding of G protein βγ-subunits to pleckstrin homology domains

The Journal of biological chemistry, 1994-04, Vol.269 (14), p.10217-10220

1994

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Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization

Receptors & channels, 1997, Vol.5 (3-4), p.193

1997

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Activation of the cloned muscarinic potassium channel by G protein βγ subunits

Nature (London), 1994-07, Vol.370 (6485), p.143-146

1994

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Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

Mitogenic signaling via G protein-coupled receptors

Model Systems for the Study of Seven-Transmembrane-Segment Receptors

Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein

2001: An AAP (Association of American Physicians) odyssey

J018 The deubiquitinases USP33 and USP20 collaboratively regulate beta2 adrenergic receptor recycling and resensitization

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

β2-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids

Site-directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor: localization of regions involved in G protein-receptor coupling

Protein kinases that phosphorylate activated G protein‐coupled receptors

G Proteins in Medicine

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding

A mutation-induced activated state of the β2-adrenergic receptor : extending the ternary complex model

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor: phosphorylation of the receptor and regulation of its mRNA level

The subunit story thickens

Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation (∗)

Binding of G protein βγ-subunits to pleckstrin homology domains

Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization

Activation of the cloned muscarinic potassium channel by G protein βγ subunits

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