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Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis

The FEBS journal, 2021-01, Vol.288 (1), p.310-324

2021

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Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Nature communications, 2021-02, Vol.12 (1), p.947-947, Article 947

2021

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Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures

Journal of inherited metabolic disease, 2022-03, Vol.45 (2), p.318-333

2022

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Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47

Biochimica et biophysica acta, 2016-04, Vol.1857 (4), p.387-395

2016

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Redox- and Ligand Binding-Dependent Conformational Ensembles in the Human Apoptosis-Inducing Factor Regulate Its Pro-Life and Cell Death Functions

Antioxidants & redox signaling, 2019-06, Vol.30 (18), Article ars.2018.7658

2019

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Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)

Biochimica et biophysica acta. General subjects, 2018-06, Vol.1862 (6), p.1283-1295

2018

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Rational stabilization of complex proteins: a divide and combine approach

Scientific reports, 2015-03, Vol.5 (1), p.9129-9129, Article 9129

2015

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Allosteric inhibitors of the NS3 protease from the hepatitis C virus

PloS one, 2013-07, Vol.8 (7), p.e69773

2013

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Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

The Journal of clinical investigation, 2008-08, Vol.118 (8), p.2858-2867

2008

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A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease

Proteins, structure, function, and bioinformatics, 2004-05, Vol.55 (3), p.594-602

2004

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MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

Epigenetics & chromatin, 2019-10, Vol.12 (1), p.63-63, Article 63

2019

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Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2

Biomolecules (Basel, Switzerland), 2021-08, Vol.11 (8), p.1216

2021

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Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/FMN Adenylyltransferase From Corynebacterium ammoniagenes

Cell biochemistry and biophysics, 2013, Vol.65 (1), p.57-68

2013

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Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome: IMPLICATIONS OF THE STABILITY AND Ca²⁺ AFFINITY OF THE FIFTH BINDING MODULE OF THE LDL RECEPTOR

The Journal of biological chemistry, 2008-08, Vol.283 (33), p.22670-22679

2008

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GrpE N-terminal Domain Contributes to the Interaction with DnaK and Modulates the Dynamics of the Chaperone Substrate Binding Domain

Journal of molecular biology, 2007-12, Vol.374 (4), p.1054-1064

2007

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Stability and binding of the phosphorylated species of the N-terminal domain of enzyme I and the histidine phosphocarrier protein from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system

Archives of biochemistry and biophysics, 2012-10, Vol.526 (1), p.44-53

2012

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Incorporating target heterogeneity in drug design

Journal of cellular biochemistry, 2001, Vol.84 (S37), p.82-88

2001

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Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome

Archives of biochemistry and biophysics, 2017-12, Vol.636, p.17-27

2017

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Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2

Nucleic acids research, 2024-04, Vol.52 (7), p.3636-3653

2024

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Structure-Function Analysis of Escherichia coli MnmG (GidA), a Highly Conserved tRNA-Modifying Enzyme

Journal of Bacteriology, 2009-12, Vol.191 (24), p.7614-7619

2009

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Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity

PloS one, 2011-09, Vol.6 (9), p.e23877-e23877

2011

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Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier

International journal of nanomedicine, 2015-01, Vol.10, p.2249-2259

2015

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Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures

Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47

Redox- and Ligand Binding-Dependent Conformational Ensembles in the Human Apoptosis-Inducing Factor Regulate Its Pro-Life and Cell Death Functions

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)

Rational stabilization of complex proteins: a divide and combine approach

Allosteric inhibitors of the NS3 protease from the hepatitis C virus

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2

Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/FMN Adenylyltransferase From Corynebacterium ammoniagenes

Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome: IMPLICATIONS OF THE STABILITY AND Ca²⁺ AFFINITY OF THE FIFTH BINDING MODULE OF THE LDL RECEPTOR

GrpE N-terminal Domain Contributes to the Interaction with DnaK and Modulates the Dynamics of the Chaperone Substrate Binding Domain

Stability and binding of the phosphorylated species of the N-terminal domain of enzyme I and the histidine phosphocarrier protein from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system

Incorporating target heterogeneity in drug design

Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome

Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2

Structure-Function Analysis of Escherichia coli MnmG (GidA), a Highly Conserved tRNA-Modifying Enzyme

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier

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