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G protein—coupled receptor kinases

Cell, 1993-08, Vol.74 (3), p.409-412

Lefkowitz, Robert J.

1993

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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

The Journal of clinical investigation, 2001-04, Vol.107 (8), p.967-974

2001

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Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity

Molecular and Cellular Biology, 2000-11, Vol.20 (22), p.8352-8363

2000

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

Trends in pharmacological sciences (Regular ed.), 1993-08, Vol.14 (8), p.303-307

1993

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade

Circulation (New York, N.Y.), 1998-10, Vol.98 (17), p.1783-1789

1998

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G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation

American journal of physiology. Lung cellular and molecular physiology, 2004-02, Vol.286 (2), p.312-L319

2004

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Structure and mechanism of the G protein-coupled receptor kinases

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.23735-23738

1993

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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

The Journal of biological chemistry, 1994-03, Vol.269 (9), p.6832-6841

1994

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Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

Neuron (Cambridge, Mass.), 1999-12, Vol.24 (4), p.1029-1036

1999

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Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

Nature reviews. Neuroscience, 2001-10, Vol.2 (10), p.727-733

2001

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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase

The Journal of biological chemistry, 1993-04, Vol.268 (11), p.8256-8260

1993

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μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Nature (London), 2000-12, Vol.408 (6813), p.720-723

2000

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Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins

The Journal of biological chemistry, 1988-04, Vol.263 (11), p.4993-4996

1988

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Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

The Journal of biological chemistry, 1992-01, Vol.267 (3), p.1430-1433

1992

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Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Circulation research, 2002-10, Vol.91 (8), p.672-680

2002

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Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in beta Arrestin-2 Knock-Out Mice

The Journal of neuroscience, 2002-12, Vol.22 (23), p.10494-10500

2002

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Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

Circulation research, 2000-01, Vol.86 (1), p.43-43

2000

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Oncogene, 2001-03, Vol.20 (13), p.1532-1539

2001

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Regulation of tyrosine kinase cascades by G-protein-coupled receptors

Current opinion in cell biology, 1999-04, Vol.11 (2), p.177-183

1999

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Constitutively active mutants of the alpha 2-adrenergic receptor

The Journal of biological chemistry, 1993-08, Vol.268 (22), p.16483-16487

1993

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β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9429-9436

2002

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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

Nature (London), 1992-09, Vol.359 (6391), p.147-150

1992

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In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Circulation (New York, N.Y.), 1999-08, Vol.100 (6), p.648-653

1999

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Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase

The Journal of biological chemistry, 1992-01, Vol.267 (3), p.1422-1425

1992

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Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

The Journal of biological chemistry, 1991-08, Vol.266 (23), p.14939-14946

1991

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G protein—coupled receptor kinases

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade

G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation

Structure and mechanism of the G protein-coupled receptor kinases

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in beta Arrestin-2 Knock-Out Mice

Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

Constitutively active mutants of the alpha 2-adrenergic receptor

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

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