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The SOFA score-development, utility and challenges of accurate assessment in clinical trials

Critical care (London, England), 2019-11, Vol.23 (1), p.374-374, Article 374

2019

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Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients

Critical care (London, England), 2017-08, Vol.21 (1), p.213-213, Article 213

2017

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New Agents in Development for Sepsis: Any Reason for Hope?

Drugs (New York, N.Y.), 2020-11, Vol.80 (17), p.1751-1761

2020

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Aerosol delivery during invasive mechanical ventilation: a systematic review

Critical care (London, England), 2017-10, Vol.21 (1), p.264-264, Article 264

2017

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CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial

The Lancet infectious diseases, 2019-06, Vol.19 (6), p.620-630

2019

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Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial

Intensive care medicine, 2020-07, Vol.46 (7), p.1425-1437

2020

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Clinical Impact of MALDI-TOF MS Identification and Rapid Susceptibility Testing on Adequate Antimicrobial Treatment in Sepsis with Positive Blood Cultures

PloS one, 2016-05, Vol.11 (5), p.e0156299-e0156299

2016

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Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

The New England journal of medicine, 2023-10, Vol.389 (17), p.1590-1600

2023

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Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2019-10, Vol.322 (15), p.1476

2019

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sTREM-1 is a specific biomarker of TREM-1 pathway activation

Cellular & molecular immunology, 2021-08, Vol.18 (8), p.2054-2056

2021

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A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

BMJ open, 2019-02, Vol.9 (2), p.e024475

2019

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Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Critical care (London, England), 2022-10, Vol.26 (1), p.1-307, Article 307

2022

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Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death

The New England journal of medicine, 2005-09, Vol.353 (13), p.1332-1341

2005

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A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

BMC pulmonary medicine, 2020-11, Vol.20 (1), p.1-309, Article 309

2020

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Pharmacokinetic profiles of intravenous versus subcutaneous administration of low molecular weight heparin for thromboprophylaxis in critically ill patients: A randomized controlled trial

Journal of critical care, 2022-08, Vol.70, p.154029-154029, Article 154029

2022

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Optimized Antibiotic Management of Critically Ill Patients with Severe Pneumonia Following Multiplex Polymerase Chain Reaction Testing: A Prospective Clinical Exploratory Trial

Antibiotics (Basel), 2024-01, Vol.13 (1), p.67

2024

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Profile of liver cholestatic biomarkers following prolonged ketamine administration in patients with COVID-19

BMC anesthesiology, 2023-02, Vol.23 (1), p.44-44, Article 44

2023

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A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

BMC pulmonary medicine, 2020-12, Vol.20 (1), p.317-317, Article 317

2020

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The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects

PloS one, 2012-07, Vol.7 (7), p.e38682

2012

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Platypnea-orthodeoxia syndrome in a postoperative patient: a case report

Journal of medical case reports, 2021-12, Vol.15 (1), p.600-600, Article 600

2021

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Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial

Annals of the American Thoracic Society, 2018-02, Vol.15 (2), p.250-257

2018

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A Large Retrospective Assessment of Voriconazole Exposure in Patients Treated with Extracorporeal Membrane Oxygenation

Microorganisms (Basel), 2021-07, Vol.9 (7), p.1543

2021

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NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study

Biomolecules (Basel, Switzerland), 2022-07, Vol.12 (8), p.1038

2022

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Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

Microorganisms (Basel), 2022-05, Vol.10 (5), p.984

2022

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The SOFA score-development, utility and challenges of accurate assessment in clinical trials

Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients

New Agents in Development for Sepsis: Any Reason for Hope?

Aerosol delivery during invasive mechanical ventilation: a systematic review

CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial

Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial

Clinical Impact of MALDI-TOF MS Identification and Rapid Susceptibility Testing on Adequate Antimicrobial Treatment in Sepsis with Positive Blood Cultures

Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

sTREM-1 is a specific biomarker of TREM-1 pathway activation

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

Pharmacokinetic profiles of intravenous versus subcutaneous administration of low molecular weight heparin for thromboprophylaxis in critically ill patients: A randomized controlled trial

Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury

Optimized Antibiotic Management of Critically Ill Patients with Severe Pneumonia Following Multiplex Polymerase Chain Reaction Testing: A Prospective Clinical Exploratory Trial

Profile of liver cholestatic biomarkers following prolonged ketamine administration in patients with COVID-19

A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects

Platypnea-orthodeoxia syndrome in a postoperative patient: a case report

Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial

A Large Retrospective Assessment of Voriconazole Exposure in Patients Treated with Extracorporeal Membrane Oxygenation

NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

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