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The SOFA score-development, utility and challenges of accurate assessment in clinical trials

Critical care (London, England), 2019-11, Vol.23 (1), p.374-374, Article 374

2019

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Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients

Critical care (London, England), 2017-08, Vol.21 (1), p.213-213, Article 213

2017

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Adrenal function in sepsis: The retrospective Corticus cohort study

Critical care medicine, 2007-04, Vol.35 (4), p.1012-1018

2007

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New Agents in Development for Sepsis: Any Reason for Hope?

Drugs (New York, N.Y.), 2020-11, Vol.80 (17), p.1751-1761

2020

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CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial

The Lancet infectious diseases, 2019-06, Vol.19 (6), p.620-630

2019

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Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

Critical care (London, England), 2018-01, Vol.22 (1), p.8-8, Article 8

2018

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Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

The New England journal of medicine, 2023-10, Vol.389 (17), p.1590-1600

2023

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sTREM-1 is a specific biomarker of TREM-1 pathway activation

Cellular & molecular immunology, 2021-08, Vol.18 (8), p.2054-2056

2021

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A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

BMJ open, 2019-02, Vol.9 (2), p.e024475

2019

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Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Critical care (London, England), 2022-10, Vol.26 (1), p.1-307, Article 307

2022

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Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial

BMJ open, 2021-07, Vol.11 (7), p.e042921-e042921

2021

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Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death

The New England journal of medicine, 2005-09, Vol.353 (13), p.1332-1341

2005

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A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

BMC pulmonary medicine, 2020-11, Vol.20 (1), p.1-309, Article 309

2020

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Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7278

2023

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Optimized Antibiotic Management of Critically Ill Patients with Severe Pneumonia Following Multiplex Polymerase Chain Reaction Testing: A Prospective Clinical Exploratory Trial

Antibiotics (Basel), 2024-01, Vol.13 (1), p.67

2024

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A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

BMC pulmonary medicine, 2020-12, Vol.20 (1), p.317-317, Article 317

2020

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Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial

Annals of the American Thoracic Society, 2018-02, Vol.15 (2), p.250-257

2018

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Tracking the foreign body, a rare cause of hepatic abscess

BMC gastroenterology, 2014-09, Vol.14 (1), p.167-167, Article 167

2014

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What stops us from following sedation recommendations in intensive care units? A multicentric qualitative study

Journal of critical care, 2014-04, Vol.29 (2), p.291-297

2014

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Pattern of Paracetamol Poisoning: Influence on Outcome and Complications

Toxics (Basel), 2018-09, Vol.6 (4), p.58

2018

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Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

Microorganisms (Basel), 2022-05, Vol.10 (5), p.984

2022

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International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety

Journal of critical care, 2007-06, Vol.22 (2), p.142-152

2007

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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Journal of intensive care, 2016-03, Vol.4 (24), p.24-24, Article 24

2016

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Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury

Intensive care medicine, 2018-05, Vol.44 (5), p.598-605

2018

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The SOFA score-development, utility and challenges of accurate assessment in clinical trials

Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients

Adrenal function in sepsis: The retrospective Corticus cohort study

New Agents in Development for Sepsis: Any Reason for Hope?

CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

sTREM-1 is a specific biomarker of TREM-1 pathway activation

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial

Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit

Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill

Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury

Optimized Antibiotic Management of Critically Ill Patients with Severe Pneumonia Following Multiplex Polymerase Chain Reaction Testing: A Prospective Clinical Exploratory Trial

A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial

Tracking the foreign body, a rare cause of hepatic abscess

What stops us from following sedation recommendations in intensive care units? A multicentric qualitative study

Pattern of Paracetamol Poisoning: Influence on Outcome and Complications

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury

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