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Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours

British journal of cancer, 2014-08, Vol.111 (5), p.894-902

2014

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The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Cell death and differentiation, 2010-11, Vol.17 (11), p.1795-1804

2010

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A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1 Mek-1 Erk1 2 pathway

Oncogene, 2007-05, Vol.26 (26), p.3777-3788

2007

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Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

Oncogene, 2014-01, Vol.33 (5), p.550-555

2014

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Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

Oncogene, 2007-02, Vol.26 (5), p.633-640

2007

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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

Cancer research (Chicago, Ill.), 1999-10, Vol.59 (19), p.4919-4926

1999

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

Oncogene, 1998-03, Vol.16 (11), p.1467-1473

1998

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The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

Leukemia, 2003-02, Vol.17 (2), p.451-457

2003

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Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

Cancer cell, 2005-04, Vol.7 (4), p.297-300

Sebti, Saïd M.

2005

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Oncogene, 1997-09, Vol.15 (11), p.1283-1288

1997

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Inhibiting ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes

Cancer research (Chicago, Ill.), 1998-04, Vol.58 (8), p.1754-1761

1998

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Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion

Cancer research (Chicago, Ill.), 1995-10, Vol.55 (19), p.4243-4247

1995

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (13), p.4394-4399

2004

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

Oncogene, 2000-12, Vol.19 (56), p.6584-6593

2000

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The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts

Cancer research (Chicago, Ill.), 1996-04, Vol.56 (8), p.1727-1730

1996

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Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

Journal of medicinal chemistry, 1999-04, Vol.42 (8), p.1333-1340

1999

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Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression

Molecular biology of the cell, 2000-11, Vol.11 (11), p.3835-3848

2000

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Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

Hepatology (Baltimore, Md.), 2000-01, Vol.31 (1), p.131-140

2000

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The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status

Cell death and differentiation, 2002-07, Vol.9 (7), p.702-709

2002

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Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice

The Journal of biological chemistry, 2000-06, Vol.275 (24), p.17974-17978

2000

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Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Oncogene, 2005-07, Vol.24 (29), p.4701-4709

2005

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Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E -tocotrienol

Carcinogenesis (New York), 2013-04, Vol.34 (4), p.858-863

2013

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In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

The Journal of clinical investigation, 2003-08, Vol.112 (3), p.407-414

2003

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New approaches to anticancer drug design based on the inhibition of farnesyltransferase

Drug discovery today, 1998, Vol.3 (1), p.26-33

1998

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Design and Synthesis of Non-Peptide Ras CAAX Mimetics as Potent Farnesyltransferase Inhibitors

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.217-223

1996

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Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1 Mek-1 Erk1 2 pathway

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Inhibiting ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts

Potent, Highly Selective, and Non-Thiol Inhibitors of Protein Geranylgeranyltransferase-I

Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression

Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status

Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E -tocotrienol

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

New approaches to anticancer drug design based on the inhibition of farnesyltransferase

Design and Synthesis of Non-Peptide Ras CAAX Mimetics as Potent Farnesyltransferase Inhibitors

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