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Synthesis of 1‑(tert-Butyl) 4‑Methyl (1R,2S,4R)‑2-Methylcyclohexane-1,4-dicarboxylate from Hagemann’s tert-Butyl Ester for an Improved Synthesis of BMS-986251

Journal of organic chemistry, 2020-08, Vol.85 (16), p.10988-10993

2020

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Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N‑(Acyloxy)phthalimides

Journal of organic chemistry, 2018-03, Vol.83 (5), p.3000-3012

2018

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Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

Journal of the American Chemical Society, 2020-02, Vol.142 (6), p.3094-3103

2020

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Ligand-Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts

Angewandte Chemie (International ed.), 2016-01, Vol.55 (2), p.785-789

International ed. in English, 2016

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Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

Journal of organic chemistry, 2021-01, Vol.86 (2), p.1730-1747

2021

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3814-3830

2010

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Intramolecular [2+2] Cycloaddition of N‐Allylcinnamamines and N‐Allylcinnamamides by Visible‐Light Photocatalysis

European journal of organic chemistry, 2020-01, Vol.2020 (1), p.41-46

2020

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Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.1270-1280

2010

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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2265-2269

2019

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Discovery of 2,6–difluorobenzyl ether series of phenyl ((R)–3–phenylpyrrolidin–3–yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (19), p.127441-127441, Article 127441

2020

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Identification and Preclinical Pharmacology of ((1R,3S)‑1-Amino-3-((S)‑6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2265-2285

2019

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Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.1701-1733

2024

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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1908-1911

2007

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The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4120-4126

2013

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Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis

Journal of the American Chemical Society, 2022-09, Vol.144 (38), p.17709-17720

2022

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Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate

ACS central science, 2016-01, Vol.2 (1), p.27-31

2016

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Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

Nature (London), 2023-11, Vol.623 (7988), p.745-751

2023

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RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

The Journal of immunology (1950), 2019-01, Vol.202 (1), p.79-92

2019

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Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3730-3742

2007

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Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (19), p.127466-127466, Article 127466

2020

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

Journal of medicinal chemistry, 2019-11, Vol.62 (21), p.9931-9946

2019

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One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent

Organic letters, 2019-11, Vol.21 (22), p.9198-9202

2019

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Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1205-1207

2023

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Tricyclic-Carbocyclic RORγt Inverse AgonistsDiscovery of BMS-986313

Journal of medicinal chemistry, 2021-03, Vol.64 (5), p.2714-2724

2021

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Synthesis of 1‑(tert-Butyl) 4‑Methyl (1R,2S,4R)‑2-Methylcyclohexane-1,4-dicarboxylate from Hagemann’s tert-Butyl Ester for an Improved Synthesis of BMS-986251

Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N‑(Acyloxy)phthalimides

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

Ligand-Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Intramolecular [2+2] Cycloaddition of N‐Allylcinnamamines and N‐Allylcinnamamides by Visible‐Light Photocatalysis

Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists

Discovery of 2,6–difluorobenzyl ether series of phenyl ((R)–3–phenylpyrrolidin–3–yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists

Identification and Preclinical Pharmacology of ((1R,3S)‑1-Amino-3-((S)‑6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design

Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold

The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode

Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis

Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent

Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Tricyclic-Carbocyclic RORγt Inverse AgonistsDiscovery of BMS-986313

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