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Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2021-10, Vol.49, p.128212-128212, Article 128212

2021

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Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling

Arteriosclerosis, thrombosis, and vascular biology, 2019-04, Vol.39 (4), p.e130

2019

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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.284

2021

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Integration of Fe 3 O 4 with Bi 2 S 3 for Multi-Modality Tumor Theranostics

ACS applied materials & interfaces, 2020-05, Vol.12 (20), p.22650-22660

2020

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Studying the effect of PDA@CeO 2 nanoparticles with antioxidant activity on the mechanical properties of cells

Journal of materials chemistry. B, Materials for biology and medicine, 2021-11, Vol.9 (44), p.9204-9212

2021

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Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18

Autophagy, 2010-11, Vol.6 (8), p.1032-1041

2010

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H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles

Marine drugs, 2018-10, Vol.16 (10)

2018

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Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

Circulation research, 2019-07, Vol.125 (3), p.309-327

2019

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Reactive oxygen species induced Ca 2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

American journal of physiology. Lung cellular and molecular physiology, 2018-05, Vol.314 (5), p.L893-L907

2018

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Re: SUCCINCT: An Open-Label, Single-Arm, Non-Randomised, Phase 2 Trial of Gemcitabine and Cisplatin Chemotherapy in Combination with Sunitinib as First-Line Treatment for Patients with Advanced Urothelial Carcinoma

The Journal of urology, 2015-12, Vol.194 (6), p.1583-1585

Chang, Sam S., MD

2015

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Phthalocyanine-mediated photodynamic therapy induces cell death and a G0/G1 cell cycle arrest in cervical cancer cells

Biochemical and biophysical research communications, 2006-01, Vol.339 (2), p.569-576

2006

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InCl 3 mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

European journal of medicinal chemistry, 2019-07, Vol.174, p.198

2019

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Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca 2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (9), p.2551

2018

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5-Nitro-5'hydroxy-indirubin-3'oxime is a novel inducer of somatic cell transdifferentiation

Archiv der Pharmazie (Weinheim), 2014-11, Vol.347 (11), p.806-818

2014

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Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

BMC pharmacology, 2010-10, Vol.10 (1), p.14-14, Article 14

2010

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The chemical toxicological analysis of sertindole

Sudebno-meditsinskaia ekspertiza, 2016-01, Vol.59 (1), p.35

2016

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Tumor suppression by small molecule inhibitors of translation initiation

Oncotarget, 2012-08, Vol.3 (8), p.869-881

2012

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In vitro photodynamic effects of phthalocyaninatosilicon covalently linked to 2,2,6,6-tetramethyl-1-piperidinyloxy radicals on cancer cells

Free radical biology & medicine, 2005-04, Vol.38 (7), p.920-927

2005

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Preclinical study of safety of the new pharmacological substance AV0012 to treat hepatitis C

Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2014, Vol.77 (12), p.33

2014

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Intravenous repeated-dose toxicity study of ZnPcS2P2-based-photodynamic therapy in beagle dogs

Regulatory toxicology and pharmacology, 2007-04, Vol.47 (3), p.221-231

2007

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Hematologic adverse effects in patients with renal cell carcinoma treated with sunitinib

Zhong hua yi xue za zhi, 2013-03, Vol.93 (12), p.902-905

2013

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GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum

Analytical and bioanalytical chemistry, 2015-01, Vol.407 (3), p.761-778

2015

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Toxicity change patterns and its mechanism during the degradation of nitrogen-heterocyclic compounds by O(3)/UV

Chemosphere (Oxford), 2007-10, Vol.69 (5), p.747

2007

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Pharmacoepidemiological and toxicological aspects of atypical neuroleptics usage

Przeglad lekarski, 2011, Vol.68 (8), p.475

2011

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Pharmacokinetic profile of a new diclofenac prodrug without gastroulcerogenic effect

Drug metabolism letters, 2012, Vol.6 (4), p.235

2012

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Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer’s disease

Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling

Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia

Integration of Fe 3 O 4 with Bi 2 S 3 for Multi-Modality Tumor Theranostics

Studying the effect of PDA@CeO 2 nanoparticles with antioxidant activity on the mechanical properties of cells

Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18

H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

Reactive oxygen species induced Ca 2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

Re: SUCCINCT: An Open-Label, Single-Arm, Non-Randomised, Phase 2 Trial of Gemcitabine and Cisplatin Chemotherapy in Combination with Sunitinib as First-Line Treatment for Patients with Advanced Urothelial Carcinoma

Phthalocyanine-mediated photodynamic therapy induces cell death and a G0/G1 cell cycle arrest in cervical cancer cells

InCl 3 mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca 2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease

5-Nitro-5'hydroxy-indirubin-3'oxime is a novel inducer of somatic cell transdifferentiation

Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

The chemical toxicological analysis of sertindole

Tumor suppression by small molecule inhibitors of translation initiation

In vitro photodynamic effects of phthalocyaninatosilicon covalently linked to 2,2,6,6-tetramethyl-1-piperidinyloxy radicals on cancer cells

Preclinical study of safety of the new pharmacological substance AV0012 to treat hepatitis C

Intravenous repeated-dose toxicity study of ZnPcS2P2-based-photodynamic therapy in beagle dogs

Hematologic adverse effects in patients with renal cell carcinoma treated with sunitinib

GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum

Toxicity change patterns and its mechanism during the degradation of nitrogen-heterocyclic compounds by O(3)/UV

Pharmacoepidemiological and toxicological aspects of atypical neuroleptics usage

Pharmacokinetic profile of a new diclofenac prodrug without gastroulcerogenic effect

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