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Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes

Endocrine reviews, 2019-04, Vol.40 (2), p.447-475

2019

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Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Steroids, 2014-01, Vol.79, p.49-63

2014

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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.315-324

2010

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5β-Dihydrosteroids: Formation and Properties

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8857

2024

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AKR1C3 as a target in castrate resistant prostate cancer

The Journal of steroid biochemistry and molecular biology, 2013-09, Vol.137, p.136-149

2013

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Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

The Journal of steroid biochemistry and molecular biology, 2022-07, Vol.221, p.106121-106121, Article 106121

2022

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Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Archives of biochemistry and biophysics, 2007-08, Vol.464 (2), p.241-250

2007

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Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Molecular and cellular endocrinology, 2019-06, Vol.489, p.1-2

2019

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Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1873

2023

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AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Molecular and cellular endocrinology, 2019-06, Vol.489, p.82-91

Penning, Trevor M.

2019

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Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Annals of the New York Academy of Sciences, 2009-02, Vol.1155 (1), p.33-42

2009

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Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Clinical cancer research, 2019-01, Vol.25 (1), p.426-439

2019

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Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (5), p.2815-2825

2006

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AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Molecular cancer therapeutics, 2018-09, Vol.17 (9), p.1833-1845

2018

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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Metabolism, clinical and experimental, 2019-10, Vol.99, p.67-80

2019

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Aldo-keto reductase (AKR) superfamily: genomics and annotation

Human genomics, 2009-07, Vol.3 (4), p.362-370, Article 362

2009

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Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Biochemical journal, 2014-08, Vol.462 (1), p.163-171

2014

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Promiscuity and diversity in 3-ketosteroid reductases

The Journal of steroid biochemistry and molecular biology, 2015-07, Vol.151, p.93-101

2015

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Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010-2017

BMC cancer, 2022-05, Vol.22 (1), p.555-555, Article 555

2022

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Association of multi-criteria derived air toxics hazard score with lung cancer incidence in a major metropolitan area

Frontiers in public health, 2023-06, Vol.11, p.1002597-1002597

2023

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Aldo-Keto Reductases and Cancer Drug Resistance

Pharmacological reviews, 2021-07, Vol.73 (3), p.1150-1171

2021

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Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC)

The Journal of steroid biochemistry and molecular biology, 2015-09, Vol.153, p.105-113

Penning, Trevor M.

2015

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Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency

Biochemical journal, 2015-05, Vol.468 (1), p.25-31

2015

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Free radical biology & medicine, 2015-11, Vol.88 (Pt B), p.108-146

2015

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Liquid chromatography–mass spectrometry (LC–MS) of steroid hormone metabolites and its applications

The Journal of steroid biochemistry and molecular biology, 2010-08, Vol.121 (3-5), p.546-555

2010

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Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes

Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

5β-Dihydrosteroids: Formation and Properties

AKR1C3 as a target in castrate resistant prostate cancer

Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Aldo-keto reductase (AKR) superfamily: genomics and annotation

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Promiscuity and diversity in 3-ketosteroid reductases

Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010-2017

Association of multi-criteria derived air toxics hazard score with lung cancer incidence in a major metropolitan area

Aldo-Keto Reductases and Cancer Drug Resistance

Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC)

Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Liquid chromatography–mass spectrometry (LC–MS) of steroid hormone metabolites and its applications

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