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Aldo-keto reductases and bioactivation/detoxication

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.263-292

2007

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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.315-324

2010

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5β-Dihydrosteroids: Formation and Properties

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8857

2024

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The aldo-keto reductases (AKRs): Overview

Chemico-biological interactions, 2015-06, Vol.234, p.236-246

Penning, Trevor M.

2015

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AKR1C3 as a target in castrate resistant prostate cancer

The Journal of steroid biochemistry and molecular biology, 2013-09, Vol.137, p.136-149

2013

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Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

The Journal of steroid biochemistry and molecular biology, 2022-07, Vol.221, p.106121-106121, Article 106121

2022

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Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Molecular and cellular endocrinology, 2019-06, Vol.489, p.1-2

2019

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Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Archives of biochemistry and biophysics, 2007-08, Vol.464 (2), p.241-250

2007

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Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1873

2023

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AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Molecular and cellular endocrinology, 2019-06, Vol.489, p.82-91

Penning, Trevor M.

2019

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Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

PloS one, 2015-07, Vol.10 (7), p.e0131093

2015

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Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Clinical cancer research, 2019-01, Vol.25 (1), p.426-439

2019

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Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (5), p.2815-2825

2006

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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Metabolism, clinical and experimental, 2019-10, Vol.99, p.67-80

2019

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AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Molecular cancer therapeutics, 2018-09, Vol.17 (9), p.1833-1845

2018

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Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Biochemical journal, 2014-08, Vol.462 (1), p.163-171

2014

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Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

Toxicology research (Cambridge), 2017, Vol.6 (6), p.74-754

Penning, Trevor M

2017

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Aldo-keto reductase (AKR) superfamily: genomics and annotation

Human genomics, 2009-07, Vol.3 (4), p.362-370, Article 362

2009

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Promiscuity and diversity in 3-ketosteroid reductases

The Journal of steroid biochemistry and molecular biology, 2015-07, Vol.151, p.93-101

2015

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Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010-2017

BMC cancer, 2022-05, Vol.22 (1), p.555-555, Article 555

2022

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The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer

Chemico-biological interactions, 2015-06, Vol.234, p.332-338

2015

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Aldo-Keto Reductases and Cancer Drug Resistance

Pharmacological reviews, 2021-07, Vol.73 (3), p.1150-1171

2021

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Association of multi-criteria derived air toxics hazard score with lung cancer incidence in a major metropolitan area

Frontiers in public health, 2023-06, Vol.11, p.1002597-1002597

2023

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AKR1B10: A new diagnostic marker of non-small cell lung carcinoma in smokers

Clinical cancer research, 2005-03, Vol.11 (5), p.1687-1690

PENNING, Trevor M

2005

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Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC)

The Journal of steroid biochemistry and molecular biology, 2015-09, Vol.153, p.105-113

Penning, Trevor M.

2015

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Aldo-keto reductases and bioactivation/detoxication

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

5β-Dihydrosteroids: Formation and Properties

The aldo-keto reductases (AKRs): Overview

AKR1C3 as a target in castrate resistant prostate cancer

Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

Aldo-keto reductase (AKR) superfamily: genomics and annotation

Promiscuity and diversity in 3-ketosteroid reductases

Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010-2017

The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer

Aldo-Keto Reductases and Cancer Drug Resistance

Association of multi-criteria derived air toxics hazard score with lung cancer incidence in a major metropolitan area

AKR1B10: A new diagnostic marker of non-small cell lung carcinoma in smokers

Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC)

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