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Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

American Journal of Physiology: Cell Physiology, 2018-09, Vol.315 (3), p.C343-C356

2018

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Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

The AAPS journal, 2017-07, Vol.19 (4), p.910-920

2017

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Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

The AAPS journal, 2017-07, Vol.19 (4), p.931-939

2017

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Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis

Clinical science (1979), 2024-09, Vol.138 (17), p.1089-1110

2024

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Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

Clinical science (1979), 2024-02, Vol.138 (4), p.205-223

2024

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HIV-1 Viral Envelope Glycoprotein gp120 Triggers an Inflammatory Response in Cultured Rat Astrocytes and Regulates the Functional Expression of P-Glycoprotein

Molecular pharmacology, 2006-09, Vol.70 (3), p.1087-1098

2006

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In Situ Localization of P-glycoprotein (ABCB1) in Human and Rat Brain

The journal of histochemistry and cytochemistry, 2006-10, Vol.54 (10), p.1159-1167

2006

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Hypoxia/Reoxygenation Stress Signals an Increase in Organic Anion Transporting polypeptide 1a4 (Oatp1a4) at the Blood–Brain Barrier: Relevance to CNS Drug Delivery

Journal of cerebral blood flow and metabolism, 2014-04, Vol.34 (4), p.699-707

2014

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Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

Molecular pharmacology, 2013-11, Vol.84 (5), p.774-786

2013

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Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

Journal of neuroscience research, 2009-03, Vol.87 (4), p.1023-1036

2009

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Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier

The Journal of pharmacology and experimental therapeutics, 2011-03, Vol.336 (3), p.827-839

2011

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The role of oxidative stress in blood–brain barrier disruption during ischemic stroke: Antioxidants in clinical trials

Biochemical pharmacology, 2024-10, Vol.228, p.116186, Article 116186

2024

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Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics

Expert opinion on drug delivery, 2024, Vol.21 (1), p.71-89

2024

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Targeted drug delivery to treat pain and cerebral hypoxia

Pharmacological reviews, 2013-01, Vol.65 (1), p.291-314

2013

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Drug delivery to the ischemic brain

Advances in pharmacology (1990), 2014, Vol.71, p.165-202

2014

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Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor- β Signaling in Human Endothelial Cells

The Journal of pharmacology and experimental therapeutics, 2021-02, Vol.376 (2), p.148-160

2021

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Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats

Experimental neurology, 2022-11, Vol.357, p.114181-114181, Article 114181

2022

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Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress

Fluids and barriers of the CNS, 2017-03, Vol.14 (1), p.6, Article 6

2017

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Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV-1 infection

Glia, 2008-12, Vol.56 (16), p.1711-1735

2008

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Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery

Organic Cation Transporters in the Central Nervous System, 2021, Vol.266, p.301-328

2021

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Functional Expression of Organic Anion Transporting Polypeptide 1a4 Is Regulated by Transforming Growth Factor- β /Activin Receptor-like Kinase 1 Signaling at the Blood-Brain Barrier

Molecular pharmacology, 2018-12, Vol.94 (6), p.1321-1333

2018

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Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood–brain barrier via the activin receptor-like kinase-1 receptor

Journal of cerebral blood flow and metabolism, 2017-07, Vol.37 (7), p.2340-2345

2017

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Methods to Study Drug Uptake at the Blood-Brain Barrier Following Experimental Ischemic Stroke: In Vitro and In Vivo Approaches

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2616, p.403

2023

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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- β /Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)

Drug metabolism and disposition, 2022-07, Vol.50 (7), p.942-956

2022

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Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain

Journal of cerebral blood flow and metabolism, 2009-06, Vol.29 (6), p.1084-1098

2009

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Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis

Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

HIV-1 Viral Envelope Glycoprotein gp120 Triggers an Inflammatory Response in Cultured Rat Astrocytes and Regulates the Functional Expression of P-Glycoprotein

In Situ Localization of P-glycoprotein (ABCB1) in Human and Rat Brain

Hypoxia/Reoxygenation Stress Signals an Increase in Organic Anion Transporting polypeptide 1a4 (Oatp1a4) at the Blood–Brain Barrier: Relevance to CNS Drug Delivery

Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier

The role of oxidative stress in blood–brain barrier disruption during ischemic stroke: Antioxidants in clinical trials

Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics

Targeted drug delivery to treat pain and cerebral hypoxia

Drug delivery to the ischemic brain

Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor- β Signaling in Human Endothelial Cells

Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats

Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress

Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV-1 infection

Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery

Functional Expression of Organic Anion Transporting Polypeptide 1a4 Is Regulated by Transforming Growth Factor- β /Activin Receptor-like Kinase 1 Signaling at the Blood-Brain Barrier

Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood–brain barrier via the activin receptor-like kinase-1 receptor

Methods to Study Drug Uptake at the Blood-Brain Barrier Following Experimental Ischemic Stroke: In Vitro and In Vivo Approaches

Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- β /Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)

Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain

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