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Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells

The Journal of biological chemistry, 2024-10, p.107867, Article 107867

2024

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Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

Biomolecules (Basel, Switzerland), 2024-09, Vol.14 (9), p.1187

2024

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Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

The Journal of biological chemistry, 2024-06, Vol.300 (6), p.107347, Article 107347

Radisky, Evette S.

2024

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Abstract 1954 Deciphering Selectivity in Mesotrypsin Inhibition: Validating an allosteric mechanism through mutation and enzyme kinetics

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106112, Article 106112

2024

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Abstract 1734 Investigating the catalytic activity of PRSS23 as a novel serine protease in ovarian cancer

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106189, Article 106189

2024

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Abstract 1331 Engineering Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Variants with Improved Binding Selectivity toward Matrix Metalloproteinase-9 (MMP-9) as potential protein therapeutics

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106870, Article 106870

2024

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Abstract 1740 Characterizing the role of matrix metalloproteinase-3 (MMP-3) in the pathogenesis of acute respiratory distress syndrome (ARDS)

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106190, Article 106190

2024

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Abstract 1915 Allosteric inhibition of serine proteases: a case study with the pro-oncogenic enzyme mesotrypsin

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106108, Article 106108

2024

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Engineering Selective TIMPs Using a Counter-Selective Screening Strategy

Methods in molecular biology (Clifton, N.J.), 2024, Vol.2747, p.257

2024

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Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix Metalloproteinase Inhibitor

Journal of molecular biology, 2023-07, Vol.435 (13), p.168095-168095, Article 168095

2023

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Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

Journal of molecular biology, 2023-07, Vol.435 (13), p.168095, Article 168095

2023

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The roles of proteases in prostate cancer

IUBMB life, 2023-06, Vol.75 (6), p.493-513

2023

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Scientific reports, 2023-03, Vol.13 (1), p.5186-5186, Article 5186

2023

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Abstract 1941: Approaches to produce functional recombinant human serine protease PRSS23 catalytic domain

The Journal of biological chemistry, 2023, Vol.299 (3), p.103286, Article 103286

2023

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Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma

Matrix biology, 2022-08, Vol.111, p.207-225

2022

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Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102146-102146, Article 102146

2022

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Structural and computational investigation of MMP‐3 affinity improvements with an engineered TIMP‐1 inhibitor

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Developing a recombinant expression system for human serine protease PRSS23

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10

The Journal of biological chemistry, 2022-03, Vol.298 (3), p.101654, Article 101654

2022

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Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes

Journal of the American Chemical Society, 2021-10, Vol.143 (41), p.17261-17275

2021

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Abstract 2515: MMP1 and TGF-β1 cooperate to drive tumor progression in large cell carcinoma of the lung through fibroblast senescence

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.2515-2515

2021

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MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence

Cancer letters, 2021-06, Vol.507, p.1-12

2021

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Structural and Computational Investigations of an Autoinhibitory Loop in Human Mesorypsin

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.02942

2021

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Targeting an autocrine IL-6–SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

Oncogene, 2020-10, Vol.39 (42), p.6606-6618

2020

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Abstract 5099: Large-cell neuroendocrine carcinoma cells of the lung induce a tumor-promoting senescent phenotype in fibroblasts through MMP1 overexpression and TGFβ1

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.5099-5099

2020

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Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

Abstract 1954 Deciphering Selectivity in Mesotrypsin Inhibition: Validating an allosteric mechanism through mutation and enzyme kinetics

Abstract 1734 Investigating the catalytic activity of PRSS23 as a novel serine protease in ovarian cancer

Abstract 1331 Engineering Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Variants with Improved Binding Selectivity toward Matrix Metalloproteinase-9 (MMP-9) as potential protein therapeutics

Abstract 1740 Characterizing the role of matrix metalloproteinase-3 (MMP-3) in the pathogenesis of acute respiratory distress syndrome (ARDS)

Abstract 1915 Allosteric inhibition of serine proteases: a case study with the pro-oncogenic enzyme mesotrypsin

Engineering Selective TIMPs Using a Counter-Selective Screening Strategy

Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix Metalloproteinase Inhibitor

Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

The roles of proteases in prostate cancer

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Abstract 1941: Approaches to produce functional recombinant human serine protease PRSS23 catalytic domain

Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma

Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma

Structural and computational investigation of MMP‐3 affinity improvements with an engineered TIMP‐1 inhibitor

Developing a recombinant expression system for human serine protease PRSS23

Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10

Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes

Abstract 2515: MMP1 and TGF-β1 cooperate to drive tumor progression in large cell carcinoma of the lung through fibroblast senescence

MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence

Structural and Computational Investigations of an Autoinhibitory Loop in Human Mesorypsin

Targeting an autocrine IL-6–SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

Abstract 5099: Large-cell neuroendocrine carcinoma cells of the lung induce a tumor-promoting senescent phenotype in fibroblasts through MMP1 overexpression and TGFβ1

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