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Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

Annual review of nutrition, 2016-07, Vol.36 (1), p.275-299

2016

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Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice

Journal of lipid research, 2018-09, Vol.59 (9), p.1714-1728

2018

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Antiatherogenic properties of flavonoids: Implications for cardiovascular health

Canadian journal of cardiology, 2010-03, Vol.26, p.17A-21A

2010

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The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

Journal of lipid research, 2020-03, Vol.61 (3), p.387-402

2020

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Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance

Diabetes (New York, N.Y.), 2009-10, Vol.58 (10), p.2198-2210

2009

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Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr−/− mice[S]

Journal of lipid research, 2013-03, Vol.54 (3), p.711-724

2013

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Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21

Endocrinology (Philadelphia), 2015-06, Vol.156 (6), p.2087-2102

2015

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PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Journal of lipid research, 2014-07, Vol.55 (7), p.1254-1266

2014

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molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin

Journal of lipid research, 2007-03, Vol.48 (3), p.699-708

2007

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Selective Up-regulation of LXR-regulated Genes ABCA1, ABCG1, and APOE in Macrophages through Increased Endogenous Synthesis of 24(S),25-Epoxycholesterol

The Journal of biological chemistry, 2007-02, Vol.282 (8), p.5207-5216

2007

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Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

Diabetes (New York, N.Y.), 2005-06, Vol.54 (6), p.1676-1683

2005

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Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation

PPAR Research, 2012-01, Vol.2012 (2012), p.770-778

2012

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Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP

Journal of lipid research, 2001-05, Vol.42 (5), p.725-734

2001

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Apolipoprotein C-III: Going Back to the Future for a Lipid Drug Target

Circulation research, 2013-05, Vol.112 (11), p.1405-1408

2013

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PCSK9: Regulation and Target for Drug Development for Dyslipidemia

Annual review of pharmacology and toxicology, 2017-01, Vol.57 (1), p.223-244

2017

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Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Diabetes (New York, N.Y.), 2003-10, Vol.52 (10), p.2554-2561

2003

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Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor

Journal of lipid research, 2008-10, Vol.49 (10), p.2218-2229

2008

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Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair‐Fed Ldlr−/− Mice

Molecular nutrition & food research, 2019-03, Vol.63 (6), p.e1800833-n/a

2019

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Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms

Biochemical journal, 2002-09, Vol.366 (Pt 2), p.531-539

2002

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Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

Diabetes (New York, N.Y.), 2011-05, Vol.60 (5), p.1446-1457

2011

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Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr−/− mice

Atherosclerosis, 2019-07, Vol.286, p.60-70

2019

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APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians

Journal of lipid research, 2010-04, Vol.51 (4), p.843-848

2010

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Polygenic determinants of severe hypertriglyceridemia

Human molecular genetics, 2008-09, Vol.17 (18), p.2894-2899

2008

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Gene Therapy for Hypercholesterolemia: Sweet Dreams and Flying Machines

Circulation research, 2014-08, Vol.115 (6), p.542-545

2014

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A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia

Human molecular genetics, 2009-11, Vol.18 (21), p.4189-4194

2009

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Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice

Antiatherogenic properties of flavonoids: Implications for cardiovascular health

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK[S]

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance

Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr−/− mice[S]

Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21

PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin

Selective Up-regulation of LXR-regulated Genes ABCA1, ABCG1, and APOE in Macrophages through Increased Endogenous Synthesis of 24(S),25-Epoxycholesterol

Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation

Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP

Apolipoprotein C-III: Going Back to the Future for a Lipid Drug Target

PCSK9: Regulation and Target for Drug Development for Dyslipidemia

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor

Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair‐Fed Ldlr−/− Mice

Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr−/− mice

APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians

Polygenic determinants of severe hypertriglyceridemia

Gene Therapy for Hypercholesterolemia: Sweet Dreams and Flying Machines

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia

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