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High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

Diabetologia, 2015-09, Vol.58 (9), p.2074-2078

2015

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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84

The FASEB journal, 2019-11, Vol.33 (11), p.12264-12276

2019

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Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Diabetologia, 2019-01, Vol.62 (1), p.99-111

2019

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A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

Biochemical journal, 2011-04, Vol.435 (1), p.267-276

2011

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Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

Islets, 2012-05, Vol.4 (3), p.177-187

2012

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Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

Trends in endocrinology and metabolism, 2014-08, Vol.25 (8), p.389-398

2014

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Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Diabetes (New York, N.Y.), 2008-11, Vol.57 (11), p.3034-3044

2008

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Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes

Diabetes (New York, N.Y.), 2005-09, Vol.54 (9), p.2755-2763

2005

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Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

Diabetes (New York, N.Y.), 2005-10, Vol.54 (10), p.2917-2924

2005

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Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

Diabetes (New York, N.Y.), 2009-08, Vol.58 (8), p.1826-1834

2009

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Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

Diabetes (New York, N.Y.), 2001-10, Vol.50 (10), p.2237-2243

2001

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Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

Diabetes (New York, N.Y.), 2008-07, Vol.57 (7), p.1774-1783

2008

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β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

iScience, 2023-04, Vol.26 (4), p.106477-106477, Article 106477

2023

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Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

The Journal of biological chemistry, 2013-09, Vol.288 (37), p.26569-26582

2013

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Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

Diabetes (New York, N.Y.), 2002-04, Vol.51 (4), p.977-987

2002

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Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

Diabetes (New York, N.Y.), 2013-05, Vol.62 (5), p.1557-1568

2013

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A Selective Look at Autophagy in Pancreatic β -Cells

Diabetes (New York, N.Y.), 2021-06, Vol.70 (6), p.1229-1241

2021

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A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

Diabetes (New York, N.Y.), 2001-10, Vol.50 (10), p.2210-2218

2001

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Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy

The Journal of biological chemistry, 2019-01, Vol.294 (4), p.1218-1229

2019

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SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Science translational medicine, 2020-09, Vol.12 (559)

2020

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High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

The Journal of biological chemistry, 2018-04, Vol.293 (15), p.5731

2018

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Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

Cell metabolism, 2019-01, Vol.29 (1), p.183-191.e7

2019

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Sweet and Sour β-Cells: ROS and Hif1α Induce Warburg-Like Lactate Production During Type 2 Diabetes

Diabetes (New York, N.Y.), 2013-06, Vol.62 (6), p.1823-1825

2013

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The diverse roles of protein kinase C in pancreatic beta-cell function

Biochemical Society transactions, 2008-10, Vol.36 (Pt 5), p.916-919

2008

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High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes

Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

A Selective Look at Autophagy in Pancreatic β -Cells

A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Treatment of type 2 diabetes with the designer cytokine IC7Fc

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

Sweet and Sour β-Cells: ROS and Hif1α Induce Warburg-Like Lactate Production During Type 2 Diabetes

The diverse roles of protein kinase C in pancreatic beta-cell function

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