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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Science (American Association for the Advancement of Science), 2017-01, Vol.355 (6320), p.89-92

2017

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Allosteric inhibition of HIV-1 integrase activity

Current opinion in chemical biology, 2013-06, Vol.17 (3), p.339-345

2013

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Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

The Journal of biological chemistry, 2008-11, Vol.283 (46), p.31802-31812

2008

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A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

The Journal of biological chemistry, 2014-09, Vol.289 (38), p.26430-26440

2014

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FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

Nucleic acids research, 2011-11, Vol.39 (20), p.9009

2011

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An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

Molecular pharmacology, 2009-10, Vol.76 (4), p.824-832

2009

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Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding

The Journal of biological chemistry, 2008-02, Vol.283 (9), p.5632-5641

2008

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Identification of an Inhibitor-Binding Site to HIV-1 Integrase with Affinity Acetylation and Mass Spectrometry

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (18), p.6894-6899

2004

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Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1354, p.149

2016

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Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

Protein science, 2016-11, Vol.25 (11), p.1911-1917

2016

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A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

The Journal of biological chemistry, 2016-11, Vol.291 (45), p.23569-23577

2016

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Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

European journal of medicinal chemistry, 2016-11, Vol.123, p.673-683

2016

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Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants

Science advances, 2023-07, Vol.9 (29), p.eadg5953-eadg5953

2023

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HIV-1 integrase multimerization as a therapeutic target

Current topics in microbiology and immunology, 2015, Vol.389, p.93

2015

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Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7949-7955

2005

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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Allosteric inhibition of HIV-1 integrase activity

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding

Identification of an Inhibitor-Binding Site to HIV-1 Integrase with Affinity Acetylation and Mass Spectrometry

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants

HIV-1 integrase multimerization as a therapeutic target

Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor

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