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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Archives of toxicology, 2020-09, Vol.94 (9), p.3281-3295

2020

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Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Archives of toxicology, 2022-01, Vol.96 (1), p.135-151

2022

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In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Chemico-biological interactions, 2020-01, Vol.315, p.108905-108905, Article 108905

2020

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Archives of toxicology, 2022-05, Vol.96 (5), p.1387-1409

2022

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Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Archives of toxicology, 2021-05, Vol.95 (5), p.1573-1593

2021

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Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Archives of toxicology, 2020-04, Vol.94 (4), p.1349-1365

2020

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Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Toxicology letters, 2023-10, Vol.388, p.30-39

2023

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Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Toxicology letters, 2021-06, Vol.343, p.34-43

2021

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Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure

Toxicology letters, 2021-02, Vol.337, p.1-6

2021

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Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Toxicological sciences, 2019-09, Vol.171 (1), p.69-83

2019

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Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants

FEMS microbiology ecology, 2022-12, Vol.99 (1)

2022

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Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Food and chemical toxicology, 2019-03, Vol.125, p.467-478

2019

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Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

British journal of pharmacology, 2015-03, Vol.172 (6), p.1607-1619

2015

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In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole

Toxicology in vitro, 2022-03, Vol.79, p.105290-105290, Article 105290

2022

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Selecting the dose metric in reverse dosimetry based QIVIVE

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2017-02, Vol.34 (2), p.135-144

2017

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Selecting the dose metric in reverse dosimetry based QIVIVE: Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: https://doi.org/10.1007/s0020 4-019-02421-w

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling

Archives of toxicology, 2017-09, Vol.91 (9), p.3093-3108

2017

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Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2022-06, Vol.39 (6), p.1021-1032

2022

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Physiologically based kinetic modeling of the bioactivation of myristicin

Archives of toxicology, 2017-02, Vol.91 (2), p.713-734

2017

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Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2017-12, Vol.34 (12), p.2201-2211

2017

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Mode of action based risk assessment of the botanical food-borne alkenylbenzene apiol from parsley using physiologically based kinetic (PBK) modelling and read-across from safrole

Food and chemical toxicology, 2016-03, Vol.89, p.138-150

2016

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P45 Circulating hydrogen sulfide is stored as labile sulfurs in albumin

Nitric oxide, 2013-09, Vol.31, p.S55-S55

2013

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OP26 Renal injury induced by nitric oxide depletion is prevented by concomitant inhibition of hydrogen sulfide and/or carbon monoxide production

Nitric oxide, 2013-09, Vol.31, p.S30-S31

2013

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P32 Propargyl glycine increases kidney weight in different rodent models of hypertension and proteinuria

Nitric oxide, 2014-05, Vol.39, p.S26-S26

2014

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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole

Selecting the dose metric in reverse dosimetry based QIVIVE

Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling

Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

Physiologically based kinetic modeling of the bioactivation of myristicin

Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill

Mode of action based risk assessment of the botanical food-borne alkenylbenzene apiol from parsley using physiologically based kinetic (PBK) modelling and read-across from safrole

P45 Circulating hydrogen sulfide is stored as labile sulfurs in albumin

OP26 Renal injury induced by nitric oxide depletion is prevented by concomitant inhibition of hydrogen sulfide and/or carbon monoxide production

P32 Propargyl glycine increases kidney weight in different rodent models of hypertension and proteinuria

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