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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Archives of toxicology, 2020-09, Vol.94 (9), p.3281-3295

2020

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Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Archives of toxicology, 2022-01, Vol.96 (1), p.135-151

2022

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In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Chemico-biological interactions, 2020-01, Vol.315, p.108905-108905, Article 108905

2020

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Archives of toxicology, 2022-05, Vol.96 (5), p.1387-1409

2022

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Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Archives of toxicology, 2020-04, Vol.94 (4), p.1349-1365

2020

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In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Current research in toxicology, 2024-01, Vol.6, p.100160-100160, Article 100160

2024

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Salt sensitivity of blood pressure: developmental and sex-related effects

The American journal of clinical nutrition, 2011-12, Vol.94 (6S), p.S1928-S1932

2011

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Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

BMC complementary medicine and therapies, 2020-03, Vol.20 (1), p.80-80, Article 80

2020

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Physiologically based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation to Predict the Effects of Aloe-Emodin in Rats and Humans

Journal of agricultural and food chemistry, 2024-07, Vol.72 (29), p.16163-16176

2024

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Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Molecular nutrition & food research, 2023-02, Vol.67 (4), p.n/a

2023

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Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Toxicology letters, 2023-10, Vol.388, p.30-39

2023

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Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Environmental science & technology, 2024-02, Vol.58 (7), p.3129-3140

2024

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Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Toxicology letters, 2021-06, Vol.343, p.34-43

2021

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Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure

Toxicology letters, 2021-02, Vol.337, p.1-6

2021

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Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Toxicological sciences, 2019-09, Vol.171 (1), p.69-83

2019

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Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants

FEMS microbiology ecology, 2022-12, Vol.99 (1)

2022

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Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

Molecular nutrition & food research, 2020-07, Vol.64 (13), p.e2000063-n/a

2020

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Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Food and chemical toxicology, 2019-03, Vol.125, p.467-478

2019

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Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

British journal of pharmacology, 2015-03, Vol.172 (6), p.1607-1619

2015

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Molecular Dynamics and In Vitro Quantification of Safrole DNA Adducts Reveal DNA Adduct Persistence Due to Limited DNA Distortion Resulting in Inefficient Repair

Chemical research in toxicology, 2020-09, Vol.33 (9), p.2298-2309

2020

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Selecting the dose metric in reverse dosimetry based QIVIVE

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans

ALTEX, alternatives to animal experimentation, 2021

Shi, Miaoying

2021

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Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Journal of applied toxicology, 2020-12, Vol.40 (12), p.1647-1660

2020

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Selecting the dose metric in reverse dosimetry based QIVIVE: Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: https://doi.org/10.1007/s0020 4-019-02421-w

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2022-06, Vol.39 (6), p.1021-1032

2022

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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Salt sensitivity of blood pressure: developmental and sex-related effects

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Physiologically based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation to Predict the Effects of Aloe-Emodin in Rats and Humans

Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants

Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

Molecular Dynamics and In Vitro Quantification of Safrole DNA Adducts Reveal DNA Adduct Persistence Due to Limited DNA Distortion Resulting in Inefficient Repair

Selecting the dose metric in reverse dosimetry based QIVIVE

A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

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