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Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

ChemMedChem, 2014-11, Vol.9 (11), p.2497-2508

2014

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Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Nature communications, 2018-12, Vol.9 (1), p.5232-16, Article 5232

2018

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In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes

Drug metabolism and disposition, 2007-12, Vol.35 (12), p.2252

2007

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Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?

Chemical research in toxicology, 2020-04, Vol.33 (4), p.955-966

2020

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An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline

ACS medicinal chemistry letters, 2022-08, Vol.13 (8), p.1278-1285

2022

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Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1141

2010

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Correction to “An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline”

ACS medicinal chemistry letters, 2023-12, Vol.14 (12), p.1891-1892

2023

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Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects

Journal of pharmaceutical and biomedical analysis, 2018-02, Vol.150, p.248-257

2018

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Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders

Journal of medicinal chemistry, 2018-05, Vol.61 (10), p.4436-4455

2018

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Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.4977-4986

2011

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Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group

European journal of medicinal chemistry, 2019-11, Vol.181, p.111576-111576, Article 111576

2019

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Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1345-1357

2015

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Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products

Journal of pharmaceutical and biomedical analysis, 2017-01, Vol.132, p.66-71

2017

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Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9756-9783

2018

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Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study

Journal of pharmaceutical and biomedical analysis, 2014-08, Vol.97, p.141-150

2014

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New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone

Xenobiotica, 2018-05, Vol.48 (5), p.478-487

2018

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Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

ChemMedChem, 2017-09, Vol.12 (18), p.1542-1554

2017

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Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate

Chromatographia, 2017-10, Vol.80 (10), p.1535-1544

2017

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Development and validation of a solid-phase extraction and gas chromatography–tandem mass spectrometry method for the determination of isopropyl-9H-thioxanthen-9-one in carton packaged milk

Journal of Chromatography A, 2008-12, Vol.1214 (1), p.128-133

2008

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Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites

Journal of pharmaceutical and biomedical analysis, 2013-05, Vol.78-79, p.233-242

2013

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A Concise Synthesis of Pyrazole Analogues of CombretastatinA1 as Potent Anti-Tubulin Agents

ChemMedChem, 2013-04, Vol.8 (4), p.633

2013

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New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement

European journal of pharmaceutical sciences, 2016-03, Vol.84, p.123-131

2016

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In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite

Xenobiotica, 2011-03, Vol.41 (3), p.212-225

2011

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In vitro metabolism study of 2-isopropyl-9 H -thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite

Xenobiotica, 2011-03, Vol.41 (3), p.212-225

2011

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Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes

Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?

An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline

Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4

Correction to “An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline”

Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity

Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues

Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group

Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis

Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study

New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone

Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

Semicarbazide Hydrochloride as Impurity in Drug Substances: a Validated LC-DAD-UV Method for Its Determination in Carbazochrome and Carbazochrome Sodium Sulfonate

Development and validation of a solid-phase extraction and gas chromatography–tandem mass spectrometry method for the determination of isopropyl-9H-thioxanthen-9-one in carton packaged milk

Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites

A Concise Synthesis of Pyrazole Analogues of CombretastatinA1 as Potent Anti-Tubulin Agents

New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement

In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite

In vitro metabolism study of 2-isopropyl-9 H -thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite

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