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IGF binding proteins in cancer: mechanistic and clinical insights

Nature reviews. Cancer, 2014-05, Vol.14 (5), p.329

Baxter, Robert C

2014

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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nature medicine, 2012-11, Vol.18 (11), p.1643-1650

2012

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Noncoding RNA actions through IGFs and IGF binding proteins in cancer

Oncogene, 2022-06, Vol.41 (25), p.3385-3393

2022

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Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Nature reviews. Endocrinology, 2015-03, Vol.11 (3), p.161

2015

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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Nature communications, 2015-04, Vol.6 (1), p.6780-6780, Article 6780

2015

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Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

Gene therapy, 2014-09, Vol.21 (9), p.811-819

2014

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A critical role for IGF-II in memory consolidation and enhancement

Nature (London), 2011-01, Vol.469 (7331), p.491-497

2011

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Oxygen-Induced Retinopathy in Mice : Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration

Pediatric research, 2009-03, Vol.65 (3), p.307-310

2009

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CHK1 inhibition exacerbates replication stress induced by IGF blockade

Oncogene, 2022-01, Vol.41 (4), p.476-488

2022

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IGF-IR: a new prognostic biomarker for human glioblastoma

British journal of cancer, 2015-09, Vol.113 (5), p.729-737

2015

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TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Nature communications, 2015-08, Vol.6 (1), p.7951-7951, Article 7951

2015

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Does height and IGF-I determine pubertal timing in girls?

Pediatric research, 2021-07, Vol.90 (1), p.176-183

2021

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Determinants of IGF-II influencing stability, receptor binding and activation

Scientific reports, 2022-03, Vol.12 (1), p.4695-4695, Article 4695

2022

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SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

Nature communications, 2018-08, Vol.9 (1), p.1-13, Article 3440

2018

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Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Nature communications, 2022-07, Vol.13 (1), p.4434-4434, Article 4434

2022

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Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Nature communications, 2022-09, Vol.13 (1), p.5415-22, Article 5415

2022

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Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration

Cell death and differentiation, 2020-08, Vol.27 (8), p.2344-2362

2020

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IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Nature (London), 2007-08, Vol.448 (7157), p.1015-1021

2007

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IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

Nature neuroscience, 2006-11, Vol.9 (11), p.1371-1381

2006

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A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS Fli1-regulated microRNAs

Oncogene, 2011-12, Vol.30 (49), p.4910-4920

2011

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rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

Gene therapy, 2016-03, Vol.23 (3), p.247-255

2016

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IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR

Oncogene, 2011-05, Vol.30 (20), p.2345-2355

2011

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Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Nature communications, 2023-10, Vol.14 (1), p.6271-6271, Article 6271

2023

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Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

British journal of cancer, 2020-03, Vol.122 (5), p.624-629

2020

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IGF binding proteins in cancer: mechanistic and clinical insights

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Noncoding RNA actions through IGFs and IGF binding proteins in cancer

Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

A critical role for IGF-II in memory consolidation and enhancement

Oxygen-Induced Retinopathy in Mice : Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration

CHK1 inhibition exacerbates replication stress induced by IGF blockade

IGF-IR: a new prognostic biomarker for human glioblastoma

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Does height and IGF-I determine pubertal timing in girls?

Determinants of IGF-II influencing stability, receptor binding and activation

SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS Fli1-regulated microRNAs

rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

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