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Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation

Biochimica et biophysica acta. Molecular cell research, 2024-10, p.119863, Article 119863

2024

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Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

The Journal of biological chemistry, 2024-09, Vol.300 (11), p.107842, Article 107842

2024

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High resolution analysis of proteolytic substrate processing

The Journal of biological chemistry, 2024-09, Vol.300 (11), p.107812, Article 107812

2024

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EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Oncogene, 2024-08, Vol.43 (36), p.2722-2736

2024

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Journal of medical virology, 2024-09, Vol.96 (9), p.e29926-n/a

2024

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Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

International journal of biological macromolecules, 2024-11, Vol.280 (Pt 2), p.135514, Article 135514

2024

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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16712-16736

2024

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Targeted nanoliposomes of oncogenic protein degraders: Significant inhibition of tumor in lung-cancer bearing mice

Journal of controlled release, 2024-12, Vol.376, p.502-517

2024

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KRAS takes the road to destruction

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1274-1275

2024

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Conformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis

Journal of molecular biology, 2024-10, p.168837, Article 168837

2024

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A novel simple fluorometric protease assay for monitoring hydrolysis of proteins in real time

Analytical biochemistry, 2025-01, Vol.696, p.115688, Article 115688

2025

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Recent advances in dual PROTACs degrader strategies for disease treatment

European journal of medicinal chemistry, 2024-12, Vol.279, p.116901, Article 116901

2024

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Selective and Orally Bioavailable c‑Met PROTACs for the Treatment of c‑Met-Addicted Cancer

Journal of medicinal chemistry, 2024-10, Vol.67 (19), p.17053-17069

2024

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Improvement of the production of pequi almond (Caryocar brasiliense Camb.) protein hydrolysates through ultrasound-assisted enzymolysis: Impact on hydrolysis kinetics, structure and functional properties of hydrolysates

Process biochemistry (1991), 2024-12, Vol.147, p.381-390

2024

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Impacts of Seasons and Regions on the Physicochemical, Microbiological and Sensory Characteristics of Kars Fresh Kashar Cheeses

International dairy journal, 2024-10, p.106120, Article 106120

2024

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Nitric oxide action in the digestive fluid of Nepenthes × ventrata is linked to the modulation of ROS level

Plant physiology and biochemistry, 2024-11, Vol.216, p.109088, Article 109088

2024

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Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC)

Journal of medicinal chemistry, 2024-08, Vol.67 (16), p.13666-13680

2024

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Exploring the oil-water interfacial behaviour of pea protein-guar gum/gellan gum mixtures relating to stability and in vitro protein digestion of model pea milk system

International journal of biological macromolecules, 2024-12, Vol.282 (Pt 1), p.136749, Article 136749

2024

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Discovery of orally bioavailable ALK PROTACs based ceritinib against ALK positive cancers

European journal of medicinal chemistry, 2024-12, Vol.279, p.116827, Article 116827

2024

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Differences in the growth, acidification, and proteolytic activities of Lactobacillus helveticus, Lactobacillus delbrueckii subsp. bulgaricus, and Streptococcus thermophilus in camel and cow milk fermentation

International dairy journal, 2025-01, Vol.160, p.106075, Article 106075

2025

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PROTAC as a novel anti-cancer strategy by targeting aging-related signaling

Seminars in cancer biology, 2024-11, Vol.106-107, p.143-155

2024

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Scientific reports, 2024-09, Vol.14 (1), p.20824-16, Article 20824

2024

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A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1452

2024

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Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

The Journal of biological chemistry, 2024-10, Vol.300 (10), p.107763, Article 107763

2024

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N-degron pathways

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2408697121

Varshavsky, Alexander

2024

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Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation

Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

High resolution analysis of proteolytic substrate processing

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Targeted nanoliposomes of oncogenic protein degraders: Significant inhibition of tumor in lung-cancer bearing mice

KRAS takes the road to destruction

Conformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis

A novel simple fluorometric protease assay for monitoring hydrolysis of proteins in real time

Recent advances in dual PROTACs degrader strategies for disease treatment

Selective and Orally Bioavailable c‑Met PROTACs for the Treatment of c‑Met-Addicted Cancer

Improvement of the production of pequi almond (Caryocar brasiliense Camb.) protein hydrolysates through ultrasound-assisted enzymolysis: Impact on hydrolysis kinetics, structure and functional properties of hydrolysates

Impacts of Seasons and Regions on the Physicochemical, Microbiological and Sensory Characteristics of Kars Fresh Kashar Cheeses

Nitric oxide action in the digestive fluid of Nepenthes × ventrata is linked to the modulation of ROS level

Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC)

Exploring the oil-water interfacial behaviour of pea protein-guar gum/gellan gum mixtures relating to stability and in vitro protein digestion of model pea milk system

Discovery of orally bioavailable ALK PROTACs based ceritinib against ALK positive cancers

Differences in the growth, acidification, and proteolytic activities of Lactobacillus helveticus, Lactobacillus delbrueckii subsp. bulgaricus, and Streptococcus thermophilus in camel and cow milk fermentation

PROTAC as a novel anti-cancer strategy by targeting aging-related signaling

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

N-degron pathways

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