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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym®, a Mechanistic Model of Drug‐Induced Liver Injury

CPT: pharmacometrics and systems pharmacology, 2016-01, Vol.5 (1), p.31-39

2016

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A Mechanistic Model of Drug‐Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

CPT: pharmacometrics and systems pharmacology, 2014-02, Vol.3 (2), p.1-8

2014

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De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption

The American journal of clinical nutrition, 1999-11, Vol.70 (5), p.928-936

1999

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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

CPT: pharmacometrics and systems pharmacology, 2014-07, Vol.3 (7), p.1-8

2014

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The inhibition of gluconeogenesis following alcohol in humans

American journal of physiology: endocrinology and metabolism, 1998-11, Vol.275 (5), p.E897-E907

1998

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VLDL-triglyceride production after alcohol ingestion, studied using [2-13C1] glycerol

Journal of lipid research, 1998-12, Vol.39 (12), p.2319-2328

1998

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The inhibition of gluconeogenesis following alcohol in humans

American journal of physiology: endocrinology and metabolism, 1998-11, Vol.38 (5), p.E897-E907

1998

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.443-459

2016

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The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury

Drug metabolism and pharmacokinetics, 2017-02, Vol.32 (1), p.40-45

2017

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Toxicological sciences, 2019-02, Vol.167 (2), p.458-467

2019

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Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

Biopharmaceutics & drug disposition, 2014-01, Vol.35 (1), p.33-49

2014

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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Journal of pharmacokinetics and pharmacodynamics, 2012-10, Vol.39 (5), p.527-541

2012

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Quantitative Prediction of Cisplatin-Induced AKI Using RENAsym, a Mechanistic Quantitative Systems Toxicology Model, and Renal Proximal Tubule Epithelial Cell In Vitro Assays: PO0234

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.124-124

2020

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An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury

The Journal of pharmacology and experimental therapeutics, 2012-08, Vol.342 (2), p.529-540

2012

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Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Pharmacology research & perspectives, 2019-12, Vol.7 (6), p.e00523-n/a

2019

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Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

Toxicological sciences, 2018-07, Vol.166 (1)

2018

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Comparing the Liver Safety Profiles of Four Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Toxicological sciences, 2022-05

2022

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Productivity Spillovers from Foreign Direct Investment: Evidence from UK Industry Level Panel Data

Journal of international business studies, 2000-01, Vol.31 (3), p.407-425

2000

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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Clinical and translational science, 2018-09, Vol.11 (5), p.498-505

2018

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Functional mechanisms of apoptosis-related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7

Journal of neuroscience research, 2005-09, Vol.81 (5), p.632-643

2005

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Treatment with Sitagliptin or Metformin Does Not Increase Body Weight despite Predicted Reductions in Urinary Glucose Excretion

Journal of diabetes science and technology, 2009-01, Vol.3 (1), p.68-82

2009

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High-Level Expression of Functional Rat Neuronal Nitric Oxide Synthase in Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (18), p.8428-8432

1995

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Linking physiology to toxicity using DILIsym super( registered ), a mechanistic mathematical model of drug-induced liver injury

Biopharmaceutics & drug disposition, 2014-01, Vol.35 (1), p.33-49

2014

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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym®, a Mechanistic Model of Drug‐Induced Liver Injury

A Mechanistic Model of Drug‐Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

The inhibition of gluconeogenesis following alcohol in humans

VLDL-triglyceride production after alcohol ingestion, studied using [2-13C1] glycerol

The inhibition of gluconeogenesis following alcohol in humans

Phylogenetic partitioning of the third-largest vertebrate genus in the world, Cyrtodactylus Gray, 1827 (Reptilia; Squamata; Gekkonidae) and its relevance to taxonomy and conservation

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Quantitative Prediction of Cisplatin-Induced AKI Using RENAsym, a Mechanistic Quantitative Systems Toxicology Model, and Renal Proximal Tubule Epithelial Cell In Vitro Assays: PO0234

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Phylogenetic partitioning of the third-largest vertebrate genus in the world, Cyrtodactylus Gray, 1827 (Reptilia; Squamata; Gekkonidae) and its relevance to taxonomy and conservation

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

Comparing the Liver Safety Profiles of Four Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Productivity Spillovers from Foreign Direct Investment: Evidence from UK Industry Level Panel Data

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

Functional mechanisms of apoptosis-related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7

Treatment with Sitagliptin or Metformin Does Not Increase Body Weight despite Predicted Reductions in Urinary Glucose Excretion

High-Level Expression of Functional Rat Neuronal Nitric Oxide Synthase in Escherichia coli

Linking physiology to toxicity using DILIsym super( registered ), a mechanistic mathematical model of drug-induced liver injury

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