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The "rights" of precision drug development for Alzheimer's disease

Alzheimer's research & therapy, 2019-08, Vol.11 (1), p.76-14, Article 76

2019

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The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

Canadian journal of neurological sciences, 2019-09, Vol.46 (5), p.499-511

2019

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Diagnosis and treatment of dementia: 2. Diagnosis

Canadian Medical Association journal, 2008-03, Vol.178 (7), p.825-836

2008

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Multidomain trials to prevent dementia: addressing methodological challenges

Alzheimer's research & therapy, 2022-07, Vol.14 (1), p.1-94, Article 94

2022

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Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY)

Alzheimer's research & therapy, 2018-09, Vol.10 (1), p.102-102, Article 102

2018

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A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease

Alzheimer's research & therapy, 2024-07, Vol.16 (1), p.151-15, Article 151

2024

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Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

Depression and anxiety, 2010-05, Vol.27 (5), p.417-425

2010

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Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia

Alzheimer's & dementia : translational research & clinical interventions, 2021, Vol.7 (1), p.e12106-n/a

2021

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Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective

Alzheimer's & dementia : translational research & clinical interventions, 2024-04, Vol.10 (2), p.e12463-n/a

2024

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Developing the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia program

Alzheimer's & dementia : translational research & clinical interventions, 2024-01, Vol.10 (1), p.e12457-n/a

2024

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Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients

Alzheimer's & dementia : translational research & clinical interventions, 2024-07, Vol.10 (3), p.e12490-n/a

2024

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CMS coverage decision on anti-amyloid monoclonal antibodies for Alzheimer disease

Nature reviews. Neurology, 2022-07, Vol.18 (7), p.379-380

2022

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Impact of potential modifications to Alzheimer's disease clinical trials in response to disruption by COVID-19: a simulation study

Alzheimer's research & therapy, 2021-12, Vol.13 (1), p.201-201, Article 201

2021

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Clinical value of Alzheimer's disease biomarker testing

Alzheimer's & dementia : translational research & clinical interventions, 2024-04, Vol.10 (2), p.e12464-n/a

2024

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Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures

Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12071-n/a

2020

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Home EEG sleep assessment shows reduced slow‐wave sleep in mild–moderate Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12347-n/a

2022

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Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia

Alzheimer's research & therapy, 2013-07, Vol.5 (Suppl 1), p.S2-S2

2013

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Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

JAMA neurology, 2015-11, Vol.72 (11), p.1324

2015

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T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12265-n/a

2022

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Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS‐Cog‐Exec

Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12059-n/a

2020

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Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial

JAMA neurology, 2022-06, Vol.79 (6), p.565

2022

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Mild Cognitive Impairment

The American journal of geriatric psychiatry, 2005-08, Vol.13 (8), p.645-655

2005

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Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation

JAMA neurology, 2024-11

2024

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Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease

Journal of Alzheimer's disease, 2024, Vol.101 (s1), p.S79-S93

2024

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Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer’s disease

Journal of neurology, neurosurgery and psychiatry, 2007-10, Vol.78 (10), p.1056-1063

2007

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The "rights" of precision drug development for Alzheimer's disease

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

Diagnosis and treatment of dementia: 2. Diagnosis

Multidomain trials to prevent dementia: addressing methodological challenges

Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY)

A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia

Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective

Developing the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia program

Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients

CMS coverage decision on anti-amyloid monoclonal antibodies for Alzheimer disease

Impact of potential modifications to Alzheimer's disease clinical trials in response to disruption by COVID-19: a simulation study

Clinical value of Alzheimer's disease biomarker testing

Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures

Home EEG sleep assessment shows reduced slow‐wave sleep in mild–moderate Alzheimer's disease

Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia

Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer's disease

Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS‐Cog‐Exec

Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial

Mild Cognitive Impairment

Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation

Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease

Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer’s disease

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