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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4773-4779

2020

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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

The Journal of biological chemistry, 2020-05, Vol.295 (20), p.6785-6797

2020

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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The Journal of biological chemistry, 2020-11, Vol.295 (47), p.16156-16165

2020

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Science translational medicine, 2022-08, Vol.14 (656), p.eabo0718

2022

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Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (43), p.26946-26954

2020

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101529-101529, Article 101529

2022

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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20509-20513

2011

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Structural basis for substrate selection by the SARS-CoV-2 replicase

Nature (London), 2023-02, Vol.614 (7949), p.781-787

2023

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Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility

Journal of virology, 2015-04, Vol.89 (8), p.4636-4644

2015

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Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α‑Carboxy Nucleoside Phosphonates

Journal of medicinal chemistry, 2015-10, Vol.58 (20), p.8110-8127

2015

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Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

The Enzymes, 2021, Vol.49, p.315-354

2021

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Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

Antimicrobial Agents and Chemotherapy, 2010-03, Vol.54 (3), p.977-983

2010

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A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2018-2027

2016

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Role of Helix P of the Human Cytomegalovirus DNA Polymerase in Resistance and Hypersusceptibility to the Antiviral Drug Foscarnet

Journal of Virology, 2006-02, Vol.80 (3), p.1440-1450

2006

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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3812-3820

2011

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Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Chemistry : a European journal, 2022-02, Vol.28 (10), p.e202104484-n/a

2022

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Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Antiviral therapy, 2011-01, Vol.16 (7), p.1123-1130

2011

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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Structural basis for substrate selection by the SARS-CoV-2 replicase

Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α‑Carboxy Nucleoside Phosphonates

Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin

Role of Helix P of the Human Cytomegalovirus DNA Polymerase in Resistance and Hypersusceptibility to the Antiviral Drug Foscarnet

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

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