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661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Scientific reports, 2017-12, Vol.7 (1), p.16855-13, Article 16855

2017

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Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3

Journal of biochemistry (Tokyo), 2022-05, Vol.171 (5), p.555-565

2022

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Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

The Journal of biological chemistry, 2018-01, Vol.293 (1), p.132-147

2018

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Functional analysis of optineurin and some of its disease‐associated mutants

IUBMB life, 2015-02, Vol.67 (2), p.120-128

2015

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Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

Communicative & integrative biology, 2018-03, Vol.11 (2), p.1-4

2018

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Umakant Waman Kenkare (1927–2019)

Current science (Bangalore), 2020-09, Vol.119 (6), p.1055-1055

Swarup, Ghanshyam

2020

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A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

Investigative ophthalmology & visual science, 2007-04, Vol.48 (4), p.1607-1614

2007

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A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress

The FEBS journal, 2021-08, Vol.288 (15), p.4576-4595

2021

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HSC70 as a sensor of low temperature: role in cold‐triggered autoinflammatory disorders

The FEBS journal, 2022-12, Vol.289 (24), p.8037-8049

2022

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Optineurin mediates negative regulation of Rab8 function by TBC1D17, a GTPase activating protein

Journal of cell science, 2012-01

2012

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Physical and Functional Interaction between Hck Tyrosine Kinase and Guanine Nucleotide Exchange Factor C3G Results in Apoptosis, Which Is Independent of C3G Catalytic Domain

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52188-52194

2003

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HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (43), p.21694-21703

2019

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Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

Biochimica et biophysica acta. Molecular basis of disease, 2022-10, Vol.1868 (10), p.166470-166470, Article 166470

2022

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Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

The Journal of biological chemistry, 2001-04, Vol.276 (14), p.10585-10588

2001

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A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α

The FEBS journal, 2023-06, Vol.290 (12), p.3110-3127

2023

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The Nobel Prize for understanding autophagy, a cellular mechanism of waste disposal that keeps us healthy

Journal of biosciences, 2016-12, Vol.41 (4), p.563-567

2016

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A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

The Journal of biological chemistry, 2017-01, Vol.292 (4), p.1218-1230

2017

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Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

Progress in molecular biology and translational science, 2023, Vol.194, p.67-78

2023

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Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Journal of cell science, 2012-11, Vol.125 (Pt 21), p.5026-5039

2012

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Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

Journal of biosciences, 2010-12, Vol.35 (4), p.501-505

2010

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Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER

Journal of cell science, 2006-05, Vol.119 (9), p.1703-1714

2006

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Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death

Biochemical journal, 2010-04, Vol.427 (1), p.91-104

2010

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Functional analysis of optineurin and some of its disease-associated mutants: Functional Analysis of Optineurin and its Disease-Associated Mutants

IUBMB life, 2015-02, Vol.67 (2), p.120-128

2015

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Tumor necrosis factor‐α‐induced caspase‐1 gene expression

The FEBS journal, 2007-09, Vol.274 (17), p.4396-4407

2007

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Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73

The FEBS journal, 2007-09, Vol.274 (17), p.4396-4407

2007

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661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

Functional analysis of optineurin and some of its disease‐associated mutants

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

Umakant Waman Kenkare (1927–2019)

A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress

HSC70 as a sensor of low temperature: role in cold‐triggered autoinflammatory disorders

Optineurin mediates negative regulation of Rab8 function by TBC1D17, a GTPase activating protein

Physical and Functional Interaction between Hck Tyrosine Kinase and Guanine Nucleotide Exchange Factor C3G Results in Apoptosis, Which Is Independent of C3G Catalytic Domain

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α

The Nobel Prize for understanding autophagy, a cellular mechanism of waste disposal that keeps us healthy

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death

Functional analysis of optineurin and some of its disease-associated mutants: Functional Analysis of Optineurin and its Disease-Associated Mutants

Tumor necrosis factor‐α‐induced caspase‐1 gene expression

Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73

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