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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

CPT: pharmacometrics and systems pharmacology, 2016-03, Vol.5 (3), p.93-122

2016

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Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Journal of pharmacokinetics and pharmacodynamics, 2007-02, Vol.34 (1), p.57-85

2007

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Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics, 2013-10, Vol.36 (5), p.417-419

2013

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Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-4

2013

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Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-3

2013

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Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

International journal of clinical pharmacology and therapeutics, 2006-12, Vol.44 (12), p.655-667

2006

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Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

European journal of drug metabolism and pharmacokinetics, 2000-01, Vol.25 (1), p.49-58

2000

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Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Clinical pharmacokinetics, 1999-07, Vol.37 (1), p.75-86

1999

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Population pharmacokinetic analysis of the major metabolites of capecitabine

Journal of pharmacokinetics and pharmacodynamics, 2002-02, Vol.29 (1), p.25-47

2002

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The use of population pharmacokinetics in drug development

Clinical pharmacokinetics, 1996-02, Vol.30 (2), p.81-93

1996

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Clinical pharmacokinetics, 1997-08, Vol.33 (2), p.142-152

1997

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Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

International journal of clinical pharmacology and therapeutics, 1997-10, Vol.35 (10), p.469

1997

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Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

British journal of clinical pharmacology, 2000-01, Vol.49 (1), p.39-48

2000

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Sparse sampling for assessment of drug exposure in toxicological studies

European journal of drug metabolism and pharmacokinetics, 1996-04, Vol.21 (2), p.105-111

1996

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Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

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Pharmacokinetic and pharmacodynamic data and models in clinical trials

European journal of drug metabolism and pharmacokinetics, 1993-01, Vol.18 (1), p.61-76

1993

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Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Clinical pharmacokinetics, 1985-01, Vol.10 (6), p.457-476

1985

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A mathematical model for dynamics of cardiovascular drug action : application to intravenous dihydropyridines in healthy volunteers

Journal of pharmacokinetics and biopharmaceutics, 1993-10, Vol.21 (5), p.489-514

1993

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L’architecture religieuse en Allemagne entre 1220 et 1350

Bulletin monumental, 2010, Vol.168 (3), p.227-242

Schurr, Marc Carel

2010

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Recherches récentes sur le gothique tardif (1350-1550)

Bulletin monumental, 2010, Vol.168 (3), p.243-280

Nußbaum, Norbert

2010

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Pharmacokinetic aspects of the sublingual administration of vincamine

Biopharmaceutics & drug disposition, 1990-05, Vol.11 (4), p.279-309

1990

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Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

Biometrics, 1988-09, Vol.44 (3), p.673-683

1988

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A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

British journal of clinical pharmacology, 2004-12, Vol.58 (6), p.618-631

2004

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Modelling and simulation in the development and use of anti-cancer agents : An underused tool?

Journal of pharmacokinetics and pharmacodynamics, 2004-12, Vol.31 (6), p.419-440

2004

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Pharmacokinetic/pharmacodynamic modeling in drug development

Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

Population pharmacokinetics of ibandronate in Caucasian and Japanese healthy males and postmenopausal females

Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Population pharmacokinetic analysis of the major metabolites of capecitabine

The use of population pharmacokinetics in drug development

An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

Sparse sampling for assessment of drug exposure in toxicological studies

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Pharmacokinetic and pharmacodynamic data and models in clinical trials

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

A mathematical model for dynamics of cardiovascular drug action : application to intravenous dihydropyridines in healthy volunteers

L’architecture religieuse en Allemagne entre 1220 et 1350

Recherches récentes sur le gothique tardif (1350-1550)

Pharmacokinetic aspects of the sublingual administration of vincamine

Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

Modelling and simulation in the development and use of anti-cancer agents : An underused tool?

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