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How modeling and simulation have enhanced decision making in new drug development

Journal of pharmacokinetics and pharmacodynamics, 2005-04, Vol.32 (2), p.185-197

2005

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Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors

Molecular pharmacology, 2000-09, Vol.58 (3), p.614-623

2000

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Characterization of the AMPA‐Activated Receptors Present on Motoneurons

Journal of neurochemistry, 2000-01, Vol.74 (1), p.179-191

2000

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Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-D-aspartate and γ-aminobutyric acidA receptors

Annals of neurology, 1994-02, Vol.35 (2), p.229-234

1994

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Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (20), p.9298-9302

1995

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Non-N-methyl-D-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: relationship to anticonvulsant activity

The Journal of pharmacology and experimental therapeutics, 1994-10, Vol.271 (1), p.25

1994

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FRI0392 ADVERSE EVENTS IN PATIENTS WITH OSTEOARTHRITIS TREATED WITH SUBCUTANEOUS TANEZUMAB: A POOLED ANALYSIS OF THE OVERALL POPULATION AND SELECTED SUBGROUPS FROM 3 RANDOMISED PLACEBO-CONTROLLED TRIALS

Annals of the rheumatic diseases, 2020-06, Vol.79 (Suppl 1), p.793-794

2020

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Felbamate block of the N-methyl-D-aspartate receptor

The Journal of pharmacology and experimental therapeutics, 1995-05, Vol.273 (2), p.878

1995

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In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus

The Journal of pharmacology and experimental therapeutics, 2000-01, Vol.292 (1), p.425

2000

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Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite

The Journal of pharmacology and experimental therapeutics, 1996-01, Vol.276 (1), p.161

1996

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Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons

Molecular pharmacology, 1992-04, Vol.41 (4), p.727-735

1992

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The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors

The Journal of pharmacology and experimental therapeutics, 1998-05, Vol.285 (2), p.539

1998

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Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate

The Journal of pharmacology and experimental therapeutics, 1997-03, Vol.280 (3), p.1383

1997

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Hydrophobic interactions of n-alkyl diamines with the N-methyl-D-aspartate receptor: voltage-dependent and -independent blocking sites

Molecular pharmacology, 1994-01, Vol.45 (1), p.117-124

1994

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Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo

Epilepsia (Copenhagen), 2002-04, Vol.43 (4), p.358-361

2002

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Subfornical organ and cardiovascular influences on identified septal neurons

American journal of physiology. Regulatory, integrative and comparative physiology, 1988-03, Vol.254 (3), p.544-R551

1988

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Intracellular Polyamines Mediate Inward Rectification of Ca2+- Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (20), p.9298-9302

1995

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Molecular Biology and Ontogeny of γ-Aminobutyric Acid (GABA) Receptors in the Mammalian Central Nervous System

Journal of child neurology, 2003-01, Vol.18 (1), p.39-48

2003

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Mechanism of action of the anticonvulsant felbamate: Opposing effects on N ‐methyl‐ D ‐aspartate and γ‐aminobutyric acid A receptors

Annals of neurology, 1994-02, Vol.35 (2), p.229-234

1994

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The Characteristics of Medial Septal Neurons Antidromically Identified as Projecting to the Median Eminence and their Response to Gonadal Steroids

Journal of neuroendocrinology, 1990-10, Vol.2 (5), p.575-581

1990

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Voltage‐Dependent Block of N‐Methyl‐d‐Aspartate Receptors by the Novel Anticonvulsant Dibenzylamine, a Bioactive Constituent of l‐(+)‐β‐Hydroxybutyrate

Epilepsia (Copenhagen), 2003-10, Vol.44 (10), p.1274-1279

2003

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Intracellular polyamines mediate inward rectification of Ca super(2+)-permeable alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Proceedings of the National Academy of Sciences - PNAS, 1995-01, Vol.92 (20), p.9298-9302

1995

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Subtype Selective NMDA Antagonists for the Treatment of Neurological Disease

CNS drug reviews, 1999-03, Vol.5 (s1), p.10-10

Donevan, S.

1999

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Circumventricular structures: CNS sensors of circulating peptides and autonomic control centres

Endocrinologia experimentalis, 1990-03, Vol.24 (1-2), p.19

1990

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Subfornical organ and cardiovascular influences on identified septal neurons

American Journal of Physiology: Cell Physiology, 1988-01, Vol.23 (3), p.R544-R551

1988

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How modeling and simulation have enhanced decision making in new drug development

Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors

Characterization of the AMPA‐Activated Receptors Present on Motoneurons

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-D-aspartate and γ-aminobutyric acidA receptors

Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Non-N-methyl-D-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: relationship to anticonvulsant activity

FRI0392 ADVERSE EVENTS IN PATIENTS WITH OSTEOARTHRITIS TREATED WITH SUBCUTANEOUS TANEZUMAB: A POOLED ANALYSIS OF THE OVERALL POPULATION AND SELECTED SUBGROUPS FROM 3 RANDOMISED PLACEBO-CONTROLLED TRIALS

Felbamate block of the N-methyl-D-aspartate receptor

In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus

Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite

Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons

The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors

Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate

Hydrophobic interactions of n-alkyl diamines with the N-methyl-D-aspartate receptor: voltage-dependent and -independent blocking sites

Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo

Subfornical organ and cardiovascular influences on identified septal neurons

Intracellular Polyamines Mediate Inward Rectification of Ca2+- Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors

Molecular Biology and Ontogeny of γ-Aminobutyric Acid (GABA) Receptors in the Mammalian Central Nervous System

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N ‐methyl‐ D ‐aspartate and γ‐aminobutyric acid A receptors

The Characteristics of Medial Septal Neurons Antidromically Identified as Projecting to the Median Eminence and their Response to Gonadal Steroids

Voltage‐Dependent Block of N‐Methyl‐d‐Aspartate Receptors by the Novel Anticonvulsant Dibenzylamine, a Bioactive Constituent of l‐(+)‐β‐Hydroxybutyrate

Intracellular polyamines mediate inward rectification of Ca super(2+)-permeable alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

Subtype Selective NMDA Antagonists for the Treatment of Neurological Disease

Circumventricular structures: CNS sensors of circulating peptides and autonomic control centres

Subfornical organ and cardiovascular influences on identified septal neurons

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