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Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin

Journal of neuroendocrinology, 2016-02, Vol.28 (2), p.12349-n/a

2016

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Growth hormone secretagogue receptor signalling affects high‐fat intake independently of plasma levels of ghrelin and LEAP2, in a 4‐day binge eating model

Journal of neuroendocrinology, 2019-10, Vol.31 (10), p.e12785-n/a

2019

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Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3098-3118

2022

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Toward a consensus nomenclature for ghrelin, its non‐acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor

Journal of neuroendocrinology, 2023-01, Vol.35 (1), p.e13224-n/a

2023

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Physiological significance of ghrelin revealed by studies using genetically engineered mouse models with modifications in the ghrelin system

ENDOCRINE JOURNAL, 2015-11, Vol.62 (11), p.953-963

2015

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Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Nature communications, 2022-01, Vol.13 (1), p.300-300, Article 300

2022

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Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

Nature communications, 2021-11, Vol.12 (1), p.6410-6410, Article 6410

2021

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The regulation of circulating ghrelin - with recent updates from cell-based assays

ENDOCRINE JOURNAL, 2015-02, Vol.62 (2), p.107-122

2015

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Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice

The journals of gerontology. Series A, Biological sciences and medical sciences, 2020-03, Vol.75 (4), p.621-630

2020

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The cellular and molecular bases of leptin and ghrelin resistance in obesity

Nature reviews. Endocrinology, 2017-06, Vol.13 (6), p.338-351

2017

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A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

Addiction biology, 2022-01, Vol.27 (1), p.e13033-n/a

2022

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GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Cellular and molecular life sciences : CMLS, 2022-05, Vol.79 (5), p.277, Article 277

2022

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Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Journal of endocrinology, 2014-01, Vol.220 (1), p.R1-R24

2014

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Identification, chemical synthesis, and receptor binding of a reptilian gecko ghrelin

Journal of peptide science, 2024-06, Vol.30 (6), p.e3567-n/a

2024

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Ghrelin promotes thymopoiesis during aging

The Journal of clinical investigation, 2007-10, Vol.117 (10), p.2778-2790

2007

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Is there an effect of ghrelin/ghrelin analogs on cancer? A systematic review

Endocrine-related cancer, 2016-09, Vol.23 (9), p.R393-R409

2016

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Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice

Endocrinology (Philadelphia), 2017-05, Vol.158 (5), p.1436-1449

2017

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Acylated but not des‐acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease

Journal of neurochemistry, 2016-05, Vol.137 (3), p.460-471

2016

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Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds

Pharmacological reviews, 2014-10, Vol.66 (4), p.984-1001

2014

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Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

Aging cell, 2011-12, Vol.10 (6), p.996-1010

2011

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Allosteric modulation of ghrelin receptor signaling by lipids

Nature communications, 2021-06, Vol.12 (1), p.3938-3938, Article 3938

2021

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Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.8304-8309

2012

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Pharmacological Modulation of Ghrelin to Induce Weight Loss: Successes and Challenges

Current diabetes reports, 2019-10, Vol.19 (10), p.102-11, Article 102

2019

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Ghrelin gene products and the regulation of food intake and gut motility

Pharmacological reviews, 2009-12, Vol.61 (4), p.430-481

2009

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Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus

Vitamins and hormones, 2022, Vol.118, p.369-392

Isokawa, Masako

2022

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Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin

Growth hormone secretagogue receptor signalling affects high‐fat intake independently of plasma levels of ghrelin and LEAP2, in a 4‐day binge eating model

Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor

Toward a consensus nomenclature for ghrelin, its non‐acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor

Physiological significance of ghrelin revealed by studies using genetically engineered mouse models with modifications in the ghrelin system

Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

The regulation of circulating ghrelin - with recent updates from cell-based assays

Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice

The cellular and molecular bases of leptin and ghrelin resistance in obesity

A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Identification, chemical synthesis, and receptor binding of a reptilian gecko ghrelin

Ghrelin promotes thymopoiesis during aging

Is there an effect of ghrelin/ghrelin analogs on cancer? A systematic review

Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice

Acylated but not des‐acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease

Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

Allosteric modulation of ghrelin receptor signaling by lipids

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

Pharmacological Modulation of Ghrelin to Induce Weight Loss: Successes and Challenges

Ghrelin gene products and the regulation of food intake and gut motility

Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus

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