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Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Trends in parasitology, 2013-03, Vol.29 (3), p.110-118

2013

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Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Medicinal research reviews, 2019-09, Vol.39 (5), p.1553-1602

2019

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Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines

Parasitology research (1987), 2023-12, Vol.122 (12), p.2751-2772

2023

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Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Nucleic acids research, 2017-08, Vol.45 (14), p.8378

2017

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Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1509-1522

2017

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Evaluation of the antiprotozoan properties of 5′-norcarbocyclic pyrimidine nucleosides

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (14), p.3081-3086

2017

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Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei

ChemMedChem, 2019-03, Vol.14 (6), p.621-635

2019

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Purine and pyrimidine transporters of pathogenic protozoa – conduits for therapeutic agents

Medicinal research reviews, 2020-09, Vol.40 (5), p.1679-1714

2020

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Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Trends in parasitology, 2003-05, Vol.19 (5), p.232-239

2003

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Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake

Molecular and biochemical parasitology, 2024-06, Vol.258, p.111616-111616, Article 111616

2024

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Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

European journal of medicinal chemistry, 2019-02, Vol.164, p.689-705

2019

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C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

European journal of medicinal chemistry, 2020-02, Vol.188, p.112018-112018, Article 112018

2020

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Drugs and drug resistance in African trypanosomiasis

Drug resistance updates, 2007-02, Vol.10 (1), p.30-50

2007

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Exploiting the Achilles’ heel of membrane trafficking in trypanosomes

Current opinion in microbiology, 2016-12, Vol.34, p.97-103

2016

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Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

Journal of ethnopharmacology, 2017-04, Vol.202, p.256-264

2017

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Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

European journal of medicinal chemistry, 2010-03, Vol.45 (3), p.941-956

2010

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Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3021-3035

2019

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Cloning and characterisation of the Equilibrative Nucleoside Transporter family of Trypanosoma cruzi: ultra-high affinity and selectivity to survive in the intracellular niche

Biochimica et biophysica acta. General subjects, 2018-12, Vol.1862 (12), p.2750-2763

2018

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Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

Journal of medicinal chemistry, 2023-10, Vol.66 (19), p.13452-13480

2023

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Correction to “Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model”

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18236-18236

2021

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Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

Molecular and biochemical parasitology, 2018-03, Vol.220, p.46-56

2018

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Direct, Late‐Stage Mono‐N‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites

ChemMedChem, 2021-11, Vol.16 (22), p.3396-3401

2021

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Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Cellular and molecular life sciences : CMLS, 2016-09, Vol.73 (17), p.3387-3400

2016

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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.3870-3888

2018

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Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

European journal of medicinal chemistry, 2018-04, Vol.150, p.385-402

2018

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Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

Evaluation of the antiprotozoan properties of 5′-norcarbocyclic pyrimidine nucleosides

Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei

Purine and pyrimidine transporters of pathogenic protozoa – conduits for therapeutic agents

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

Drugs and drug resistance in African trypanosomiasis

Exploiting the Achilles’ heel of membrane trafficking in trypanosomes

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Cloning and characterisation of the Equilibrative Nucleoside Transporter family of Trypanosoma cruzi: ultra-high affinity and selectivity to survive in the intracellular niche

Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

Correction to “Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model”

Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

Direct, Late‐Stage Mono‐N‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

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