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New ALKBH2 and ALKBH5 inhibitors for treating glioblastoma

Results in Chemistry, 2024-07, Vol.9, p.101645, Article 101645

2024

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MV1035 Overcomes Temozolomide Resistance in Patient-Derived Glioblastoma Stem Cell Lines

Biology (Basel, Switzerland), 2022-01, Vol.11 (1), p.70

2022

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Sodium channel blockers as therapeutic target for treating epilepsy: recent updates

Current topics in medicinal chemistry, 2012-05, Vol.12 (9), p.962-970

2012

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Potential In-vitro Antiviral Activity of MV1035 on SARS-CoV-2 Wild Type Viruses

Letters in drug design & discovery, 2023-01, Vol.20 (10), p.1656-1663

2023

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Novel sodium channel antagonists in the treatment of neuropathic pain

Expert opinion on investigational drugs, 2016-02, Vol.25 (2), p.215-226

2016

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Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines

Molecular cancer therapeutics, 2008-02, Vol.7 (2), p.361-370

2008

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Recent advances in the medicinal chemistry of sodium channel blockers and their therapeutic potential

Current topics in medicinal chemistry, 2009-03, Vol.9 (4), p.396-415

2009

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Sodium Channel Blocking Activity and In-vivo Testing of New Phenylimidazole Derivatives

Letters in drug design & discovery, 2016-11, Vol.13 (9), p.962-967

2016

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Drug repurposing approaches to fight Dengue virus infection and related diseases

Frontiers in bioscience, 2018-01, Vol.23 (6), p.997-1019, Article 4630

2018

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Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers

Letters in drug design & discovery, 2014-01, Vol.11 (1), p.90-97

2014

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In vivo screening of diarylimidazoles as anticonvulsant agents

Medicinal chemistry research, 2012-11, Vol.21 (11), p.3428-3434

2012

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A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks

Journal of organic chemistry, 2007-06, Vol.72 (12), p.4551-4553

2007

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A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4- Methylhistamine

Letters in organic chemistry, 2009-01, Vol.6 (1), p.88-89

2009

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Sodium channel blockers for neuropathic pain

Expert opinion on therapeutic patents, 2010-06, Vol.20 (6), p.755-779

2010

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Sodium channel blockers: a patent review (2010 - 2014)

Expert opinion on therapeutic patents, 2015-03, Vol.25 (3), p.279-290

2015

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Innovative 3D proteome-wide scale identification of ALKBH5 target for MV1035 small molecule able to reduce migration and invasiveness in U87 glioblastoma cell lines by SPILLO-PBSS

Biomedical Science and Engineering, 2021-09, Vol.4 (s1)

2021

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NMR analysis of a series of imidazobenzoxazines

Magnetic resonance in chemistry, 2010-06, Vol.48 (6), p.500-503

2010

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Chiral nmr discrimination of the diastereoisomeric salts of the H(3)-antagonist 2-[3-(1 H-imidazol-4-ylmethyl)piperidin-1 -yl]- 1 H-benzimidazole

Magnetic resonance in chemistry, 2009-06, Vol.47 (6), p.515-518

2009

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Chiral NMR discrimination of the diastereoisomeric salts of the H3-antagonist 2-[3-(1H-imidazol-4-ylmethyl)piperidin-1-yl]-1H-benzimidazole

Magnetic resonance in chemistry, 2009-06, Vol.47 (6), p.515-518

2009

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Chiral NMR discrimination of the diastereoisomeric salts of the H 3 ‐antagonist 2‐[3‐(1H‐imidazol‐4‐ylmethyl)piperidin‐1‐yl]‐1H‐benzimidazole

Magnetic resonance in chemistry, 2009-06, Vol.47 (6), p.515-518

2009

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Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1429-1439

2003

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Synthesis and Stability in Biological Media of 1H-Imidazole-1-carboxylates of ROS203, an Antagonist of the Histamine H3 Receptor

Chemistry & biodiversity, 2008-01, Vol.5 (1), p.140-152

2008

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Synthesis and Stability in Biological Media of 1 H ‐Imidazole‐1‐carboxylates of ROS203, an Antagonist of the Histamine H 3 Receptor

Chemistry & biodiversity, 2008-01, Vol.5 (1), p.140-152

2008

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Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT 1 and MT 2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1429-1439

2003

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ChemInform Abstract: Inhibition of Na v 1.6 Sodium Channel Currents by a Novel Series of 1,4‐Disubstituted‐triazole Derivatives Obtained via Copper‐Catalyzed Click Chemistry

ChemInform, 2013-02, Vol.44 (7)

2013

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New ALKBH2 and ALKBH5 inhibitors for treating glioblastoma

MV1035 Overcomes Temozolomide Resistance in Patient-Derived Glioblastoma Stem Cell Lines

Sodium channel blockers as therapeutic target for treating epilepsy: recent updates

Potential In-vitro Antiviral Activity of MV1035 on SARS-CoV-2 Wild Type Viruses

Novel sodium channel antagonists in the treatment of neuropathic pain

Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines

Recent advances in the medicinal chemistry of sodium channel blockers and their therapeutic potential

Sodium Channel Blocking Activity and In-vivo Testing of New Phenylimidazole Derivatives

Drug repurposing approaches to fight Dengue virus infection and related diseases

Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers

In vivo screening of diarylimidazoles as anticonvulsant agents

A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks

A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4- Methylhistamine

Sodium channel blockers for neuropathic pain

Sodium channel blockers: a patent review (2010 - 2014)

Innovative 3D proteome-wide scale identification of ALKBH5 target for MV1035 small molecule able to reduce migration and invasiveness in U87 glioblastoma cell lines by SPILLO-PBSS

NMR analysis of a series of imidazobenzoxazines

Chiral nmr discrimination of the diastereoisomeric salts of the H(3)-antagonist 2-[3-(1 H-imidazol-4-ylmethyl)piperidin-1 -yl]- 1 H-benzimidazole

Chiral NMR discrimination of the diastereoisomeric salts of the H3-antagonist 2-[3-(1H-imidazol-4-ylmethyl)piperidin-1-yl]-1H-benzimidazole

Chiral NMR discrimination of the diastereoisomeric salts of the H 3 ‐antagonist 2‐[3‐(1H‐imidazol‐4‐ylmethyl)piperidin‐1‐yl]‐1H‐benzimidazole

Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

Synthesis and Stability in Biological Media of 1H-Imidazole-1-carboxylates of ROS203, an Antagonist of the Histamine H3 Receptor

Synthesis and Stability in Biological Media of 1 H ‐Imidazole‐1‐carboxylates of ROS203, an Antagonist of the Histamine H 3 Receptor

Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT 1 and MT 2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

ChemInform Abstract: Inhibition of Na v 1.6 Sodium Channel Currents by a Novel Series of 1,4‐Disubstituted‐triazole Derivatives Obtained via Copper‐Catalyzed Click Chemistry

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