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Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Journal of the American Chemical Society, 2021-01, Vol.143 (2), p.593-598

2021

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Nature (London), 2013-11, Vol.503 (7477), p.548-551

2013

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Caspase Substrates and Cellular Remodeling

Annual review of biochemistry, 2011-07, Vol.80 (1), p.1055-1087

2011

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Redox-based reagents for chemoselective methionine bioconjugation

Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6325), p.597-602

2017

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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (45), p.28046-28055

2020

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Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (41), p.25464-25475

2020

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An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

eLife, 2018-06, Vol.7

2018

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Caspases and their substrates

Cell death and differentiation, 2017-08, Vol.24 (8), p.1380-1389

2017

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Sampling the N-terminal proteome of human blood

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (10), p.4561-4566

2010

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A reactivity-based probe of the intracellular labile ferrous iron pool

Nature chemical biology, 2016-09, Vol.12 (9), p.680

2016

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Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8477-8482

2013

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Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.E2001-E2010

2016

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Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

Nature communications, 2016-07, Vol.7 (1), p.12009-12009, Article 12009

2016

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Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (11), p.5733-5740

2020

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Nature reviews. Drug discovery, 2004-04, Vol.3 (4), p.301-317

2004

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Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells

eLife, 2022-03, Vol.11

2022

Volltextzugriff (PDF)

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

Frontiers in immunology, 2021-03, Vol.12, p.639818-639818

2021

Volltextzugriff (PDF)

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (39), p.E8174-E8183

2017

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Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast

Molecular & cellular proteomics, 2017-04, Vol.16 (4), p.512-523

2017

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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Nature communications, 2022-07, Vol.13 (1), p.4121-17, Article 4121

2022

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Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture

ACS nano, 2021-12, Vol.15 (12), p.19202-19210

2021

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Small-Molecule Activators of a Proenzyme

Science (American Association for the Advancement of Science), 2009-11, Vol.326 (5954), p.853-858

2009

Volltextzugriff (PDF)

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18590-18595

2014

Volltextzugriff (PDF)

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers

The Journal of clinical investigation, 2022-02, Vol.132 (4)

2022

Volltextzugriff (PDF)

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

Molecular & cellular proteomics, 2013-03, Vol.12 (3), p.813-824

2013

Volltextzugriff (PDF)

1 – 25 von 3.436

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Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Caspase Substrates and Cellular Remodeling

Redox-based reagents for chemoselective methionine bioconjugation

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Caspases and their substrates

Sampling the N-terminal proteome of human blood

A reactivity-based probe of the intracellular labile ferrous iron pool

Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture

Small-Molecule Activators of a Proenzyme

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

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