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Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

Current topics in medicinal chemistry, 2016-10, Vol.16 (25), p.2753-2764

2016

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Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

Molecular cancer therapeutics, 2017-09, Vol.16 (9), p.1779-1790

2017

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Heat shock protein 90 in neurodegenerative diseases

Molecular neurodegeneration, 2010-06, Vol.5 (1), p.24-24, Article 24

2010

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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Nature chemical biology, 2013-11, Vol.9 (11), p.677-684

2013

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Purine-scaffold Hsp90 inhibitors

Current topics in medicinal chemistry, 2009-11, Vol.9 (15), p.1436-1446

2009

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Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Stem cell reports, 2016-10, Vol.7 (4), p.664-677

2016

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Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Blood, 2014-03, Vol.123 (13), p.2075-2083

2014

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (20), p.8368-8373

2009

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

Nature communications, 2023-06, Vol.14 (1), p.3742-3742, Article 3742

2023

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HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Nature communications, 2018-10, Vol.9 (1), p.4345-15, Article 4345

2018

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Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6803-6818

2013

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HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

The Journal of clinical investigation, 2010-10, Vol.120 (10), p.3578-3593

2010

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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

Cell reports (Cambridge), 2020-06, Vol.31 (13), p.107840-107840, Article 107840

2020

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Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab

PloS one, 2010-01, Vol.5 (1), p.e8859

2010

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Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

Blood, 2013-10, Vol.122 (16), p.2837-2847

2013

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A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90)

PloS one, 2013-09, Vol.8 (9), p.e75446

2013

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Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Expert opinion on drug discovery, 2011-05, Vol.6 (5), p.559-587

2011

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A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Cell reports (Cambridge), 2015-12, Vol.13 (10), p.2159-2173

2015

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Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

ACS chemical biology, 2014-08, Vol.9 (8), p.1698-1705

2014

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Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90

PLoS neglected tropical diseases, 2010-06, Vol.4 (6), p.e714

2010

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Preparation of a Diverse Purine-Scaffold Library via One-Step Palladium Catalyzed Cross-Coupling

Heterocycles, 2013, Vol.87 (1), p.91

2013

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Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Beilstein journal of organic chemistry, 2013-03, Vol.9 (1), p.544-556

2013

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Epichaperome Abundance Predicts Response to the Epichaperome Inhibitor, Puh-71, in Acute Myeloid Leukemia

Blood, 2019-11, Vol.134 (Supplement_1), p.5145-5145

2019

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A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond

Cold Spring Harbor perspectives in biology, 2020-04, Vol.12 (4), p.a034116

2020

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Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

Heat shock protein 90 in neurodegenerative diseases

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Purine-scaffold Hsp90 inhibitors

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90)

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90

Preparation of a Diverse Purine-Scaffold Library via One-Step Palladium Catalyzed Cross-Coupling

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

The epichaperome is an integrated chaperome network that facilitates tumour survival

Epichaperome Abundance Predicts Response to the Epichaperome Inhibitor, Puh-71, in Acute Myeloid Leukemia

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond

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