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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Nature reviews. Drug discovery, 2014-01, Vol.13 (1), p.63-79

2014

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Transduction of mechanical and cytoskeletal cues by YAP and TAZ

Nature reviews. Molecular cell biology, 2012-09, Vol.13 (9), p.591-600

2012

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Hippo signaling: growth control and beyond

Development (Cambridge), 2011-01, Vol.138 (1), p.9-22

2011

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Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling

PLoS genetics, 2015-02, Vol.11 (2), p.e1004994

2015

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Modulating F-actin organization induces organ growth by affecting the Hippo pathway

The EMBO journal, 2011-06, Vol.30 (12), p.2325-2335

2011

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Initiation of hepatic stellate cell activation extends into chronic liver disease

Cell death & disease, 2021-11, Vol.12 (12), p.1110-1110, Article 1110

2021

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MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Nature communications, 2015-10, Vol.6 (1), p.8357, Article 8357

2015

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Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6468), p.1029-1034

2019

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Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (4), p.1437-1442

2010

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Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

Nature communications, 2015-04, Vol.6 (1), p.6683-6683, Article 6683

2015

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apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15810-15815

2010

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Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer

Nature communications, 2024-03, Vol.15 (1), p.2700-2700, Article 2700

2024

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Genes & development, 2007-11, Vol.21 (21), p.2747-2761

2007

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Tumor suppression by cell competition through regulation of the Hippo pathway

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (2), p.484-489

2012

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Differential regulation of the Hippo pathway by adherens junctions and apical–basal cell polarity modules

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (6), p.1785-1790

2015

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Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (31), p.12632-12637

2012

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A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

Molecular cancer therapeutics, 2024-01, Vol.23 (1), p.3-13

2024

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Shared enhancer gene regulatory networks between wound and oncogenic programs

eLife, 2023-05, Vol.12

2023

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YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role

International journal of molecular sciences, 2019-02, Vol.20 (3), p.638

2019

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Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (39), p.14897-14902

2008

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Discovering the Hippo pathway protein-protein interactome

Cell research, 2014-02, Vol.24 (2), p.137-138

2014

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Nature cell biology, 2003-10, Vol.5 (10), p.914-920

2003

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A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor Progression

Hepatology (Baltimore, Md.), 2021-09, Vol.74 (3), p.1445-1460

2021

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Cell Junctions in Hippo Signaling

Cold Spring Harbor perspectives in biology, 2018-05, Vol.10 (5), p.a028753

2018

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Abstract IA07: Hippo signaling in liver regeneration and liver tumors

Molecular cancer research, 2020-08, Vol.18 (8_Supplement), p.IA07-IA07

Halder, Georg

2020

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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

Hippo signaling: growth control and beyond

Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

Initiation of hepatic stellate cell activation extends into chronic liver disease

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Tumor suppression by cell competition through regulation of the Hippo pathway

Differential regulation of the Hippo pathway by adherens junctions and apical–basal cell polarity modules

Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

Shared enhancer gene regulatory networks between wound and oncogenic programs

YAP and TAZ Heterogeneity in Primary Liver Cancer: An Analysis of Its Prognostic and Diagnostic Role

Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

Discovering the Hippo pathway protein-protein interactome

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor Progression

Cell Junctions in Hippo Signaling

Abstract IA07: Hippo signaling in liver regeneration and liver tumors

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