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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8), p.2412-2417

2013

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MTL-CEBPA Combined with Immunotherapy or RFA Enhances Immunological Anti-Tumor Response in Preclinical Models

International journal of molecular sciences, 2021-09, Vol.22 (17), p.9168

2021

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A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

Molecular cancer therapeutics, 2010-01, Vol.9 (1), p.145-156

2010

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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

Cancer research (Chicago, Ill.), 2011-02, Vol.71 (3), p.1029-1040

2011

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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo

Molecular cancer therapeutics, 2012-08, Vol.11 (8), p.1650-1660

2012

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AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

Science translational medicine, 2015-11, Vol.7 (314), p.314ra185

2015

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Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

Molecular therapy, 2017-12, Vol.25 (12), p.2705-2714

2017

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Magnetic Resonance Imaging Measurements of the Response of Murine and Human Tumors to the Vascular-Targeting Agent ZD6126

Clinical cancer research, 2004-06, Vol.10 (11), p.3650-3657

2004

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Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

Oncogene, 2018-06, Vol.37 (24), p.3216-3228

2018

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Antitumor Activity of the Novel Vascular Targeting Agent ZD6126 in a Panel of Tumor Models

Clinical cancer research, 2002-06, Vol.8 (6), p.1974-1983

2002

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Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

Science translational medicine, 2017-06, Vol.9 (394)

2017

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Sensitization of Tumor-Associated Endothelial Cell Apoptosis by the Novel Vascular-Targeting Agent ZD6126 in Combination with Cisplatin

Clinical cancer research, 2004-11, Vol.10 (22), p.7671-7676

2004

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The first international conference on vascular targeting: meeting overview

Cancer research (Chicago, Ill.), 2003-03, Vol.63 (5), p.1144

2003

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Acute Tumor Response to ZD6126 Assessed by Intrinsic Susceptibility Magnetic Resonance Imaging

Neoplasia (New York, N.Y.), 2005-05, Vol.7 (5), p.466-474

2005

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ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature

Cancer research (Chicago, Ill.), 2002-12, Vol.62 (24), p.7247-7253

2002

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Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcoichinol-O-Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model

Neoplasia (New York, N.Y.), 2004-03, Vol.6 (2), p.150-157

2004

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Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.386-398

2014

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An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding

Molecular cancer therapeutics, 2011-05, Vol.10 (5), p.770-783

2011

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Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice

Cancer research (Chicago, Ill.), 2002-07, Vol.62 (13), p.3711-3715

2002

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Anti-Cancer Drug Discovery and Development Summit

Expert opinion on investigational drugs, 2003-09, Vol.12 (9), p.1577-1582

Blakey, David C

2003

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Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy

Journal of medicinal chemistry, 1995-12, Vol.38 (26), p.5051-5065

1995

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Abstract 1508: MTL-CEBPA activates the transcription factor CEBPalpha leading to inhibition of hepatocellular cancer growth

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1508-1508

2017

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Abstract A72: Novel approach for upregulation of endogenous immunostimulatory targets for cancer therapy

Cancer immunology research, 2020-03, Vol.8 (3_Supplement), p.A72-A72

2020

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ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts

Cancer research (Chicago, Ill.), 1996-07, Vol.56 (14), p.3287-3292

1996

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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

MTL-CEBPA Combined with Immunotherapy or RFA Enhances Immunological Anti-Tumor Response in Preclinical Models

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

Magnetic Resonance Imaging Measurements of the Response of Murine and Human Tumors to the Vascular-Targeting Agent ZD6126

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

Antitumor Activity of the Novel Vascular Targeting Agent ZD6126 in a Panel of Tumor Models

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial

Sensitization of Tumor-Associated Endothelial Cell Apoptosis by the Novel Vascular-Targeting Agent ZD6126 in Combination with Cisplatin

The first international conference on vascular targeting: meeting overview

Acute Tumor Response to ZD6126 Assessed by Intrinsic Susceptibility Magnetic Resonance Imaging

ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature

Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcoichinol-O-Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model

Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling

An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding

Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice

Anti-Cancer Drug Discovery and Development Summit

Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy

Abstract 1508: MTL-CEBPA activates the transcription factor CEBPalpha leading to inhibition of hepatocellular cancer growth

Abstract A72: Novel approach for upregulation of endogenous immunostimulatory targets for cancer therapy

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts

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