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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809-817

2008

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L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2252-2260

2008

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148-1155

2009

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In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2036-2043

2006

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.77-86

2002

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Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.155

2001

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Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.718

2003

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Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes

Drug metabolism and disposition, 1999-01, Vol.27 (1), p.46

1999

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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Expert opinion on drug metabolism & toxicology, 2010-11, Vol.6 (11), p.1333-1346

2010

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Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Drug metabolism and disposition, 1998-01, Vol.26 (1), p.12

1998

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Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.986-992

2003

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Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.1013

1997

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A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Chemical research in toxicology, 2000-11, Vol.13 (11), p.1103-1113

2000

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Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic, and conjugation pathways

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.830

2001

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Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450

Drug metabolism and disposition, 1998-09, Vol.26 (9), p.914

1998

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Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.779

1998

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Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice

Toxicological sciences, 2004-07, Vol.80 (1), p.3-13

2004

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Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity

Drug metabolism and disposition, 1992-09, Vol.20 (5), p.658

1992

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Characterization of the Reactivity, Regioselectivity, and Stereoselectivity of the Reactions of Butadiene Monoxide with Valinamide and the N-Terminal Valine of Mouse and Rat Hemoglobin

Chemical research in toxicology, 1999-08, Vol.12 (8), p.679-689

1999

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Oxidation of 3-Butene-1,2-diol by Alcohol Dehydrogenase

Chemical research in toxicology, 1996-10, Vol.9 (7), p.1127-1134

1996

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The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens

Molecular cancer therapeutics, 2002-11, Vol.1 (13), p.1211

2002

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Synthesis and Characterization of N-Acetyl-L-cysteine S-Conjugates of Butadiene Monoxide and Their Detection and Quantitation in Urine of Rats and Mice Given Butadiene Monoxide

Chemical research in toxicology, 1995-01, Vol.8 (1), p.68-76

1995

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In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities

Drug metabolism and disposition, 1990-11, Vol.18 (6), p.917

1990

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse

Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes

The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene

Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic, and conjugation pathways

Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450

Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes

Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice

Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity

Characterization of the Reactivity, Regioselectivity, and Stereoselectivity of the Reactions of Butadiene Monoxide with Valinamide and the N-Terminal Valine of Mouse and Rat Hemoglobin

Oxidation of 3-Butene-1,2-diol by Alcohol Dehydrogenase

The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens

Synthesis and Characterization of N-Acetyl-L-cysteine S-Conjugates of Butadiene Monoxide and Their Detection and Quantitation in Urine of Rats and Mice Given Butadiene Monoxide

In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities

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