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Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives

Current topics in medicinal chemistry, 2016-10, Vol.16 (26), p.2841-2862

2016

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Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society, 2021-05, Vol.143 (19), p.7380-7387

2021

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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6557), p.931-936

2021

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Seed coating with a neonicotinoid insecticide negatively affects wild bees

Nature (London), 2015-05, Vol.521 (7550), p.77-80

2015

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Thiazole Compounds as Antiviral Agents: An Update

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2020-01, Vol.16 (1), p.4-23

2020

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Bees prefer foods containing neonicotinoid pesticides

Nature (London), 2015-05, Vol.521 (7550), p.74-76

2015

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Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.7923-7956

2020

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9184-9204

2017

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An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.624

2021

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Thiazole Ring-A Biologically Active Scaffold

Molecules (Basel, Switzerland), 2021-05, Vol.26 (11), p.3166

2021

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Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.685

2018

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

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Substituted N‑Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7108-7122

2017

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Novel 3‑Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4488-4510

2016

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Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13316-13329

2020

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Nature communications, 2015-02, Vol.6 (1), p.6263-6263, Article 6263

2015

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Nature communications, 2016-11, Vol.7 (1), p.13312-12, Article 13312

2016

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Nature (London), 2015-02, Vol.518 (7538), p.240-244

2015

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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3548-3571

2015

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Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors

Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.559

2023

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Nature chemical biology, 2018-02, Vol.14 (2), p.163-170

2018

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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Cancer discovery, 2019-07, Vol.9 (7), p.926-943

2019

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Thiazole in the targeted anticancer drug discovery

Future medicinal chemistry, 2019-08, Vol.11 (16), p.1929-1952

2019

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Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

JAMA neurology, 2021-05, Vol.78 (5), p.558

2021

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Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives

Cancer Selective Target Degradation by Folate-Caged PROTACs

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Seed coating with a neonicotinoid insecticide negatively affects wild bees

Thiazole Compounds as Antiviral Agents: An Update

Bees prefer foods containing neonicotinoid pesticides

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Thiazole Ring-A Biologically Active Scaffold

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Substituted N‑Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

Novel 3‑Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Thiazole in the targeted anticancer drug discovery

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

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