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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Nature (London), 2020-09, Vol.585 (7824), p.293-297

2020

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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Nature communications, 2019-01, Vol.10 (1), p.131-131, Article 131

2019

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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature communications, 2020-04, Vol.11 (1), p.1996-14, Article 1996

2020

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Nature communications, 2017-10, Vol.8 (1), p.830-14, Article 830

2017

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Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

Proceedings of the National Academy of Sciences - PNAS, 2023-10, Vol.120 (40), p.e2310862120-e2310862120

2023

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Cellular quality control by the ubiquitin-proteasome system and autophagy

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6467), p.818-822

2019

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Targeted protein degradation via intramolecular bivalent glues

Nature (London), 2024-03, Vol.627 (8002), p.204-211

2024

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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Nature (London), 2014-10, Vol.514 (7524), p.646-649

2014

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Mutant-selective degradation by BRAF-targeting PROTACs

Nature communications, 2021-02, Vol.12 (1), p.920-11, Article 920

2021

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Magnetic-field-dependent quantum emission in hexagonal boron nitride at room temperature

Nature communications, 2019-01, Vol.10 (1), p.222-222, Article 222

2019

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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Nature communications, 2024-01, Vol.15 (1), p.275-19, Article 275

2024

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Regulated proteolysis of a cross-link–specific peptidoglycan hydrolase contributes to bacterial morphogenesis

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (35), p.10956-10961

2015

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Microbial tryptophan catabolites in health and disease

Nature communications, 2018-08, Vol.9 (1), p.3294-10, Article 3294

2018

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26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4228-4237

2019

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Control of ADAM17 activity by regulation of its cellular localisation

Scientific reports, 2016-10, Vol.6 (1), p.35067-35067, Article 35067

2016

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Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases

Nature communications, 2021-04, Vol.12 (1), p.2155-2155, Article 2155

2021

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Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras

Science (American Association for the Advancement of Science), 2023-10, Vol.382 (6668), p.eadf6249-eadf6249

2023

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Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Nature communications, 2017-10, Vol.8 (1), p.924-13, Article 924

2017

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Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

Nature (London), 2022-05, Vol.605 (7910), p.527-531

2022

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N-degron and C-degron pathways of protein degradation

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (2), p.358-366

Varshavsky, Alexander

2019

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Exploring the relationship between air pollution and meteorological conditions in China under environmental governance

Scientific reports, 2020-09, Vol.10 (1), Article 14518

2020

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Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (40), p.E9280-E9287

2018

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Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins

Nature communications, 2024-07, Vol.15 (1), p.5808-21, Article 5808

2024

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Control of protein stability by post-translational modifications

Nature communications, 2023-01, Vol.14 (1), p.201-201, Article 201

2023

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Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (42), p.11157-11162

2017

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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

Cellular quality control by the ubiquitin-proteasome system and autophagy

Targeted protein degradation via intramolecular bivalent glues

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Mutant-selective degradation by BRAF-targeting PROTACs

Magnetic-field-dependent quantum emission in hexagonal boron nitride at room temperature

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Regulated proteolysis of a cross-link–specific peptidoglycan hydrolase contributes to bacterial morphogenesis

Microbial tryptophan catabolites in health and disease

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

Control of ADAM17 activity by regulation of its cellular localisation

Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases

Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

N-degron and C-degron pathways of protein degradation

Exploring the relationship between air pollution and meteorological conditions in China under environmental governance

Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome

Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins

Control of protein stability by post-translational modifications

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

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