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Targeting cancer with small-molecule pan-KRAS degraders

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1338-1347

2024

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High resolution analysis of proteolytic substrate processing

The Journal of biological chemistry, 2024-09, Vol.300 (11), p.107812, Article 107812

2024

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EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Oncogene, 2024-08, Vol.43 (36), p.2722-2736

2024

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Journal of medical virology, 2024-09, Vol.96 (9), p.e29926-n/a

2024

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Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16355-16380

2024

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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16712-16736

2024

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Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

The Journal of biological chemistry, 2024-11, Vol.300 (11), p.107842, Article 107842

2024

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KRAS takes the road to destruction

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1274-1275

2024

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Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

PloS one, 2024-08, Vol.19 (8), p.e0309327

2024

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BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

Oncogene, 2024-09, Vol.43 (39), p.2914-2926

2024

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Scientific reports, 2024-09, Vol.14 (1), p.20824-16, Article 20824

2024

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A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1452

2024

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Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer

International journal of molecular sciences, 2024-10, Vol.25 (20), p.11214

2024

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The Discovery of a Specific CKIP-1 Ligand for the Potential Treatment of Disuse Osteoporosis

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8870

2024

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Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

The Journal of biological chemistry, 2024-10, Vol.300 (10), p.107763, Article 107763

2024

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N-degron pathways

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2408697121

Varshavsky, Alexander

2024

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Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Advanced materials (Weinheim), 2024-09, Vol.36 (38), p.n/a

2024

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Therapeutic potential of archaeal unfoldase PAN.sup.et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

PloS one, 2024-10, Vol.19 (10), p.e0308058

2024

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MetaDegron: multimodal feature-integrated protein language model for predicting E3 ligase targeted degrons

Briefings in bioinformatics, 2024-09, Vol.25 (6)

2024

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Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia

PLoS pathogens, 2024-10, Vol.20 (10), p.e1012617

2024

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Proteolytic degradation of seed proteins of vetch species (Vicia L. subgenus Vicia) of section Peregrinae Kupicha during SDS-electrophoresis and its prevention

Biotehnologiâ i selekciâ rastenij (Online), 2024-10, Vol.7 (3), p.5-18

2024

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EVALUATION OF PROTEOLYTIC ACTIVITY IN EXPERIMENTAL PERITONITIS WITH SEROGUARD® TREATMENT

Paëmi Sino, 2024-09, Vol.26 (3), p.417-426

2024

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ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect

Database : the journal of biological databases and curation, 2024-10, Vol.2024

2024

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Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers

Cell death & disease, 2024-10, Vol.15 (10), p.753-13, Article 753

2024

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Development of a molecular glue-based Lin28 degrader to regulate cellular proliferation and stemness

Chemical communications (Cambridge, England), 2024-10, Vol.60 (86), p.12525-12528

2024

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Targeting cancer with small-molecule pan-KRAS degraders

High resolution analysis of proteolytic substrate processing

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

KRAS takes the road to destruction

Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer

The Discovery of a Specific CKIP-1 Ligand for the Potential Treatment of Disuse Osteoporosis

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

N-degron pathways

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Therapeutic potential of archaeal unfoldase PAN.sup.et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

MetaDegron: multimodal feature-integrated protein language model for predicting E3 ligase targeted degrons

Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia

Proteolytic degradation of seed proteins of vetch species (Vicia L. subgenus Vicia) of section Peregrinae Kupicha during SDS-electrophoresis and its prevention

EVALUATION OF PROTEOLYTIC ACTIVITY IN EXPERIMENTAL PERITONITIS WITH SEROGUARD® TREATMENT

ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect

Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers

Development of a molecular glue-based Lin28 degrader to regulate cellular proliferation and stemness

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