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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Archives of toxicology, 2020-09, Vol.94 (9), p.3281-3295

2020

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Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Archives of toxicology, 2022-01, Vol.96 (1), p.135-151

2022

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Archives of toxicology, 2022-05, Vol.96 (5), p.1387-1409

2022

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Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Archives of toxicology, 2021-05, Vol.95 (5), p.1573-1593

2021

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Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Archives of toxicology, 2020-04, Vol.94 (4), p.1349-1365

2020

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In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Current research in toxicology, 2024-01, Vol.6, p.100160-100160, Article 100160

2024

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On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin

Antioxidants, 2023-08, Vol.12 (8), p.1544

2023

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Salt sensitivity of blood pressure: developmental and sex-related effects

The American journal of clinical nutrition, 2011-12, Vol.94 (6S), p.S1928-S1932

2011

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Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

BMC complementary medicine and therapies, 2020-03, Vol.20 (1), p.80-80, Article 80

2020

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Physiologically based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation to Predict the Effects of Aloe-Emodin in Rats and Humans

Journal of agricultural and food chemistry, 2024-07, Vol.72 (29), p.16163-16176

2024

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Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Molecular nutrition & food research, 2023-02, Vol.67 (4), p.n/a

2023

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Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Environmental science & technology, 2024-02, Vol.58 (7), p.3129-3140

2024

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Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

Environmental science & technology, 2023-08, Vol.57 (30), p.10974-10984

2023

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A New Approach Methodology Ibogaine-Induced Cardiotoxicity in Humans

ALTEX, alternatives to animal experimentation, 2021-09, Vol.38 (4), p.636

2021

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Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation

Environmental science & technology, 2023-12, Vol.57 (49), p.20521-20531

2023

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Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Toxicological sciences, 2019-09, Vol.171 (1), p.69-83

2019

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Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

Molecular nutrition & food research, 2020-07, Vol.64 (13), p.e2000063-n/a

2020

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Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

British journal of pharmacology, 2015-03, Vol.172 (6), p.1607-1619

2015

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Molecular Dynamics and In Vitro Quantification of Safrole DNA Adducts Reveal DNA Adduct Persistence Due to Limited DNA Distortion Resulting in Inefficient Repair

Chemical research in toxicology, 2020-09, Vol.33 (9), p.2298-2309

2020

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Selecting the dose metric in reverse dosimetry based QIVIVE

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans

ALTEX, alternatives to animal experimentation, 2021

Shi, Miaoying

2021

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Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2017-02, Vol.34 (2), p.135-144

2017

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Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Journal of applied toxicology, 2020-12, Vol.40 (12), p.1647-1660

2020

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Level of Alkenylbenzenes in Parsley and Dill Based Teas and Associated Risk Assessment Using the Margin of Exposure Approach

Journal of agricultural and food chemistry, 2016-11, Vol.64 (45), p.8640-8646

2016

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Selecting the dose metric in reverse dosimetry based QIVIVE: Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: https://doi.org/10.1007/s0020 4-019-02421-w

Archives of toxicology, 2019-05, Vol.93 (5), p.1467-1469

2019

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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin

Salt sensitivity of blood pressure: developmental and sex-related effects

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Physiologically based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation to Predict the Effects of Aloe-Emodin in Rats and Humans

Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

A New Approach Methodology Ibogaine-Induced Cardiotoxicity in Humans

Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population

Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

Molecular Dynamics and In Vitro Quantification of Safrole DNA Adducts Reveal DNA Adduct Persistence Due to Limited DNA Distortion Resulting in Inefficient Repair

Selecting the dose metric in reverse dosimetry based QIVIVE

A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans

Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Level of Alkenylbenzenes in Parsley and Dill Based Teas and Associated Risk Assessment Using the Margin of Exposure Approach

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