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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

FEBS letters, 2009-06, Vol.583 (12), p.1817-1824

2009

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The biology of IQGAP proteins: beyond the cytoskeleton

EMBO reports, 2015-04, Vol.16 (4), p.427-446

2015

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11381-11386

2011

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Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4472-4484

2018

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RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

The Journal of cell biology, 2013-09, Vol.202 (6), p.917-935

2013

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SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6686), p.eadk1291

2024

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CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Cell death & disease, 2019-11, Vol.10 (12), p.900-14, Article 900

2019

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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

eLife, 2020-06, Vol.9

2020

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Tau exacerbates excitotoxic brain damage in an animal model of stroke

Nature communications, 2017-09, Vol.8 (1), p.473-15, Article 473

2017

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Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Cell death and differentiation, 2017-01, Vol.24 (1), p.15-25

2017

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Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Human molecular genetics, 2015-07, Vol.24 (14), p.4006-4023

2015

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Sar1 GTPase Activity Is Regulated by Membrane Curvature

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1014-1027

2016

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Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Cancer research (Chicago, Ill.), 2017-08, Vol.77 (16), p.4328-4341

2017

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Journal of cell biology, 2024-09, Vol.223 (9)

2024

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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Scientific reports, 2019-06, Vol.9 (1), p.9126-15, Article 9126

2019

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Bile Acids Activate YAP to Promote Liver Carcinogenesis

Cell reports (Cambridge), 2013-11, Vol.5 (4), p.1060-1069

2013

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Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3685-3699

2018

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EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells

Cancer research (Chicago, Ill.), 2020-10, Vol.80 (20), p.4371-4385

2020

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AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

The EMBO journal, 2017-04, Vol.36 (8), p.995-1010

2017

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Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

The Journal of immunology (1950), 2009-10, Vol.183 (8), p.4879-4886

2009

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Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

Organic & biomolecular chemistry, 2019-05, Vol.17 (19), p.4879-4891

2019

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Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4822-4835

2020

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Nature communications, 2019-09, Vol.10 (1), p.3975-13, Article 3975

2019

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The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.3134-3147

2020

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

The biology of IQGAP proteins: beyond the cytoskeleton

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Sar1 GTPase Activity Is Regulated by Membrane Curvature

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Bile Acids Activate YAP to Promote Liver Carcinogenesis

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells

AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

Diversity of mechanisms in Ras-GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling

Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)

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