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Cyclosporin Structure and Permeability: From A to Z and Beyond

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13131-13151

2021

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Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8272-8286

2021

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From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7145-7159

2014

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The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.683-691

2016

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Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4'-OH)MeLeu] 4 -CsA overproduction

Microbial cell factories, 2017-07, Vol.16 (1), p.120-120, Article 120

2017

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V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

Biochemical journal, 2013-04, Vol.451 (2), p.245-255

2013

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ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport

Toxicological sciences, 2011-06, Vol.121 (2), p.343-356

2011

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Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels

Journal of the American Society of Nephrology, 2015-07, Vol.26 (7), p.1576-1587

2015

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Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

The Journal of pharmacology and experimental therapeutics, 2009-08, Vol.330 (2), p.423-429

2009

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Liquid chromatography-tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients

Journal of separation science, 2010-08, Vol.33 (15), p.2287-2293

2010

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The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

Journal of biomolecular screening, 2013-04, Vol.18 (4), p.430-440

2013

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Cyclophilin inhibitors for the treatment of HCV infection

Current opinion in investigational drugs (London, England : 2000), 2010-08, Vol.11 (8), p.911

2010

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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

Biochemistry (Easton), 1992-04, Vol.31 (16), p.3896-3901

1992

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Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

The Journal of biological chemistry, 1999-08, Vol.274 (32), p.22581-22585

1999

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Science (American Association for the Advancement of Science), 1991-01, Vol.251 (4991), p.283-287

Schreiber, Stuart L.

1991

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The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.802

1998

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Exo-Mechanism Proximity-Accelerated Alkylations: Investigations of Linkers, Electrophiles and Surface Mutations in Engineered Cyclophilin-Cyclosporin Systems

Chembiochem : a European journal of chemical biology, 2005-05, Vol.6 (5), p.890-899

2005

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Nature (London), 1989-10, Vol.341 (6244), p.758-760

1989

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Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

Nature (London), 1989-02, Vol.337 (6206), p.473-475

1989

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A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Nature (London), 1989-10, Vol.341 (6244), p.755-757

1989

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

Nature (London), 1989-02, Vol.337 (6206), p.476-478

1989

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Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5066), p.50-56

1992

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Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases

The Journal of biological chemistry, 1993-01, Vol.268 (2), p.1479-1487

1993

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Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

Nature (London), 1991-09, Vol.353 (6341), p.276-279

1991

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NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

Biochemistry (Easton), 1991-07, Vol.30 (26), p.6563-6574

1991

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Cyclosporin Structure and Permeability: From A to Z and Beyond

Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives

From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices

Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4'-OH)MeLeu] 4 -CsA overproduction

V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport

Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

Cyclophilin inhibitors for the treatment of HCV infection

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite

Exo-Mechanism Proximity-Accelerated Alkylations: Investigations of Linkers, Electrophiles and Surface Mutations in Engineered Cyclophilin-Cyclosporin Systems

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

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