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Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models

The Journal of clinical investigation, 2020-02, Vol.130 (2), p.942-957

2020

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Recent Advances in Basic Research for Brain Arteriovenous Malformation

International journal of molecular sciences, 2019-10, Vol.20 (21), p.5324

2019

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PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Nature communications, 2016-11, Vol.7 (1), p.13650-12, Article 13650

2016

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Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression

PloS one, 2014-06, Vol.9 (6), p.e98646-e98646

2014

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Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice

PloS one, 2009-12, Vol.4 (12), p.e8339-e8339

2009

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Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report

Arteriosclerosis, thrombosis, and vascular biology, 2014-10, Vol.34 (10), p.2232

2014

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Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

Scientific reports, 2016-10, Vol.6 (1), p.35444-35444, Article 35444

2016

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Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

PloS one, 2013-03, Vol.8 (3), p.e59675

2013

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Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.18940-18945

2013

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TMEM100 is a key factor for specification of lymphatic endothelial progenitors

Angiogenesis (London), 2020-08, Vol.23 (3), p.339-355

2020

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Arteriovenous malformation in the adult mouse brain resembling the human disease

Annals of neurology, 2011-06, Vol.69 (6), p.954-962

2011

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ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

Blood, 2008-01, Vol.111 (2), p.633-642

2008

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Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Nature communications, 2017-02, Vol.8 (1), p.14477-14477, Article 14477

2017

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Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse

Cerebrovascular diseases (Basel, Switzerland), 2012-01, Vol.33 (6), p.540-547

2012

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Arterial Endothelium-Specific Activin Receptor-Like Kinase 1 Expression Suggests Its Role in Arterialization and Vascular Remodeling

Circulation research, 2003-10, Vol.93 (7), p.682-689

2003

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Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

Genes & development, 2002-11, Vol.16 (21), p.2749-2754

2002

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SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension

Hypertension (Dallas, Tex. 1979), 2013-05, Vol.61 (5), p.1044-1052

2013

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PIERCE1 is critical for specification of left-right asymmetry in mice

Scientific reports, 2016-06, Vol.6 (1), p.27932-27932, Article 27932

2016

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Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2

PloS one, 2013-05, Vol.8 (5), p.e63138-e63138

2013

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Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells

Reproduction (Cambridge, England), 2009-09, Vol.138 (3), p.463-470

2009

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TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

Laboratory investigation, 2011-11, Vol.91 (11), p.1554-1563

2011

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Evolutionarily Conserved Mammalian Adenine Nucleotide Translocase 4 Is Essential for Spermatogenesis

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29658-29666

2007

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Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

Laboratory investigation, 2006-02, Vol.86 (2), p.116-129

2006

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Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Pulmonary circulation, 2022-01, Vol.12 (1), p.e12056-n/a

2022

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A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2

Human molecular genetics, 2003-03, Vol.12 (5), p.473-482

2003

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Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models

Recent Advances in Basic Research for Brain Arteriovenous Malformation

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression

Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice

Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report

Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

TMEM100 is a key factor for specification of lymphatic endothelial progenitors

Arteriovenous malformation in the adult mouse brain resembling the human disease

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse

Arterial Endothelium-Specific Activin Receptor-Like Kinase 1 Expression Suggests Its Role in Arterialization and Vascular Remodeling

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension

PIERCE1 is critical for specification of left-right asymmetry in mice

Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2

Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

Evolutionarily Conserved Mammalian Adenine Nucleotide Translocase 4 Is Essential for Spermatogenesis

Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2

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