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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Clinical pharmacology and therapeutics, 2012-06, Vol.91 (6), p.1044-1052

2012

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Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

British journal of clinical pharmacology, 2012-08, Vol.74 (2), p.304-314

2012

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In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

European journal of clinical pharmacology, 2011-08, Vol.67 (8), p.815-824

2011

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Metabolism of melatonin by human cytochromes p450

Drug metabolism and disposition, 2005-04, Vol.33 (4), p.489

2005

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Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients

Clinical pharmacology and therapeutics, 2010-11, Vol.88 (5), p.676-684

2010

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In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver

Journal of pharmaceutical sciences, 2007-02, Vol.96 (2), p.428-437

2007

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Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.533

2007

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Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey, and human

Drug metabolism and disposition, 2011-04, Vol.39 (4), p.675

2011

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Effect of regular organic solvents on cytochrome P450-mediated metabolic activities in rat liver microsomes

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.1922

2010

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A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

Clinical pharmacology and therapeutics, 2011-08, Vol.90 (2), p.221-228

2011

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Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Clinical pharmacology and therapeutics, 2005-06, Vol.77 (6), p.553-559

2005

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Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2330

2009

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Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: gender-related difference in metabolism of Schisandra lignans in rats

Drug metabolism and disposition, 2010-10, Vol.38 (10), p.1747

2010

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Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.808

2010

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Losartan increases bradykinin levels in hypertensive humans

Circulation (New York, N.Y.), 2005-01, Vol.111 (3), p.315-320

2005

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Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.782

2011

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Metabolism and excretion of asenapine in healthy male subjects

Drug metabolism and disposition, 2011-04, Vol.39 (4), p.580

2011

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Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2305

2009

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Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2399

2009

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Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.507-513

2013

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CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

European journal of clinical pharmacology, 2012-05, Vol.68 (5), p.637-644

2012

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Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

Drug metabolism and disposition, 2006-07, Vol.34 (7), p.1175

2006

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Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

British journal of clinical pharmacology, 2012-12, Vol.74 (6), p.999-1004

2012

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Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.92

2011

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GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

Therapeutic drug monitoring, 2013-08, Vol.35 (4), p.473

2013

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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

Metabolism of melatonin by human cytochromes p450

Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients

In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver

Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey, and human

Effect of regular organic solvents on cytochrome P450-mediated metabolic activities in rat liver microsomes

A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: gender-related difference in metabolism of Schisandra lignans in rats

Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state

Losartan increases bradykinin levels in hypertensive humans

Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6

Metabolism and excretion of asenapine in healthy male subjects

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

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